Clinical trialNCT05398094RecruitingPhase 2Interventional

Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and Ineligible for Chemo-radiotherapy

SponsorFundación GECPEnrollment19KRAS P.G12CNon-small Cell Lung Cancer Stage III

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Open-label, non-randomised, exploratory, phase II, multi-centre clinical trial. 43 unresectable stage III (IIIA-N2, IIIB, IIIC) KRAS p.G12C non-small cell lung cancer patients will be enrolled in this trial to evaluate the efficacy of induction treatment of AMG510 (Sotorasib) plus AMG510 (Sotorasib) treatment post-induction as measured by Progression Free Survival at 12 months.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Mariano Provencio, MD
Fundación GECP President
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

20 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Spain

Hospital General Universitario de Alicante
Alicante, Alicante, Spain
Bartomeu Massuti, MD
Recruiting
Ico Badalona, Hospital Germans Trias I Pujol
Badalona, Barcelona, Spain
Enric Carcereny, MD
Recruiting
Hospital Parc Taulí
Barcelona, Barcelona, Spain
Julia Giner, MD
Recruiting
Hospital Universitari Quiron Dexeus
Barcelona, Barcelona, Spain
Maria González, MD
Recruiting
Hospital Universitari Vall D' Hebron
Barcelona, Barcelona, Spain
Patricia Iranzo, MD
Recruiting
Hospital de Basurto
Bilbao, Bilbao, Spain
Mª Ángeles Sala, MD
Recruiting
Ico Girona, Hospital Josep Trueta
Girona, Girona, Spain
Elia Sais, MD
Recruiting
Hospital Clínico San Cecilio de Granada
Granada, Granada, Spain
Silvia Sequero, MD
Recruiting
Complejo Hospitalario de Jaén
Jaén, Jaén, Spain
Ana Laura Ortega, MD
Recruiting
Hospitalario Universitario A Coruña
A Coruña, La Coruña, Spain
Rosario García Campelo, MD
Recruiting
Hospital Universitario Lucus Augusti
Lugo, Lugo, Spain
Sergio Vázquez, MD
Recruiting
Hospital Universitario Severo Ochoa
Leganés, Madrid, Spain
Ana López, MD
Recruiting
Hospital Clínico San Carlos
Madrid, Madrid, Spain
Carlos Aguado, MD
Recruiting
Hospital Universitario Fundación Jiménez Díaz
Madrid, Madrid, Spain
Manuel Dómine, MD
Recruiting
Hospital Universitario Puerta de Hierro
Majadahonda, Madrid, Spain
Mariano Provencio, MD
Recruiting
Hospital de Son Espases
Palma de Mallorca, Mallorca, Spain
Aitor Azkárate Martínez, MD
Recruiting
Hospital Universitari Son Llatzer
Palma de Mallorca, Palma de Mallorca, Spain
Francisco Javier Garcia, MD
Recruiting
Hospital Universitario Virgen del Rocio
Seville, Sevilla, Spain
Reyes Bernabé, MD
Recruiting
Hospital General Universitario de Valencia
Valencia, Valencia, Spain
Paula Espinosa, MD
Recruiting
Hospital Universitario la Fe
Valencia, Valencia, Spain
Oscar Juan-Vidal, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Sotorasib →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 21 Mar 2022
Primary completion: 31 Dec 2027
Completion: 31 Dec 2028
Last update posted: 30 Apr 2026
Registered enrollment: 19
Registry id: NCT05398094

Cross-registrations

EU-CTR / CTIS (EudraCT)2021-004576-34

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.