Clinical trialNCT05413811CompletedInterventional

Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV

SponsorUNC Lineberger Comprehensive Cancer CenterEnrollment180CIN2CIN3Cervical CancerHuman Immunodeficiency VirusHuman Papillomavirus

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to explore whether an anti-cancer medication (5-fluorouracil cream) placed in the vagina after a surgical excision procedure is an acceptable and useful form of treatment for cervical precancer among the woman with HIV infection.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Carla Chibwesha, MD, MSc
University of North Carolina, Chapel Hill
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

South Africa

Clinical Hiv Research Unit Temba Lethu Wing Helen Joseph Hospital
Westdene, Johannesburg, South Africa

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

5 Fluorouracil CreamPlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Mar 2023
Primary completion: 30 Jun 2025
Completion: 30 Jun 2025
Last update posted: 21 Aug 2026
Registered enrollment: 180
Registry id: NCT05413811

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.