Clinical trialNCT05419518RecruitingPhase 2Interventional

Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone Metas

SponsorRutgers, The State University of New JerseyEnrollment124Metastases, NeoplasmNeoplasm Metastases

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The investigators hypothesize that with dose escalation to 40-50 Gy in ten fractions, the complete pain response rate at one month can be increased to 40-50% in painful non-spinal bone metastases. Additionally, the investigators hypothesize that utilizing a fractionation scheme with an escalated biologically equivalent dose (BED) will result in a higher proportion of participants responding to treatment, and will also lead to more durable responses. Furthermore, the investigators hypothesize that with dose escalation to 40-50 Gy in ten fractions, the complete pain response rate at one month can be increased to 35-45% in painful non-bone metastases

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Matthew P Deek, MD
Rutgers Cancer Institute of New Jersey
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Rwjbarnabas Health - Robert Wood Johnson University Hospital
Hamilton, New Jersey, United States
Not, yet, recruiting
Rwjbarnabas Health - Monmouth Medical Center Southern Campus
Lakewood, New Jersey, United States
Recruiting
Rwjbarnabas Health - Saint Barnabas Medical Center
Livingston, New Jersey, United States
Recruiting
Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
Recruiting
Robert Wood Johnson University Hospital
New Brunswick, New Jersey, United States
Recruiting
Rwjbarnabas Health - Robert Wood Johnson University Hospital
Somerset, New Jersey, United States
Recruiting
Rwjbarnabas Health - Community Medical Center
Toms River, New Jersey, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

EXTERNAL BEAM RADIATION

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 16 Mar 2023
Primary completion: 1 Apr 2027
Completion: 1 Apr 2027
Last update posted: 2 Jun 2026
Registered enrollment: 124
Registry id: NCT05419518

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.