Clinical trialNCT05486572RecruitingInterventional

Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI

SponsorVA Office of Research and DevelopmentEnrollment4,700Carcinoma, HepatocellularCirrhosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal of PREMIUM is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC. The investigators hypothesize that HCC will be detected at earlier stages, allowing for more curative treatments and resulting in a reduction in HCC-related mortality.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

George N. Ioannou, MD MS
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

34 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Birmingham Va Medical Center, Birmingham, Al
Birmingham, Alabama, United States
Recruiting
Southern Arizona Va Health Care System, Tucson, Az
Tucson, Arizona, United States
Recruiting
Central Arkansas Veterans Healthcare System , Little Rock, Ar
Little Rock, Arkansas, United States
Recruiting
Va Long Beach Healthcare System, Long Beach, Ca
Long Beach, California, United States
Recruiting
Va Palo Alto Health Care System, Palo Alto, Ca
Palo Alto, California, United States
Recruiting
Va Northern California Health Care System, Mather, Ca
Sacramento, California, United States
Recruiting
Va San Diego Healthcare System, San Diego, Ca
San Diego, California, United States
Recruiting
Va Greater Los Angeles Healthcare System, West Los Angeles, Ca
West Los Angeles, California, United States
Recruiting
Rocky Mountain Regional Va Medical Center, Aurora, Co
Aurora, Colorado, United States
Recruiting
Va Connecticut Healthcare System West Haven Campus, West Haven, Ct
West Haven, Connecticut, United States
Recruiting
Washington Dc Va Medical Center, Washington, Dc
Washington D.C., District of Columbia, United States
Recruiting
Miami Va Healthcare System, Miami, Fl
Miami, Florida, United States
Recruiting
James A. Haley Veterans' Hospital, Tampa, Fl
Tampa, Florida, United States
Active, not recruiting
Atlanta Va Medical and Rehab Center, Decatur, Ga
Decatur, Georgia, United States
Recruiting
Robley Rex Va Medical Center, Louisville, Ky
Louisville, Kentucky, United States
Recruiting
Baltimore Va Medical Center Va Maryland Health Care System, Baltimore, Md
Baltimore, Maryland, United States
Recruiting
Va Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, Ma
Boston, Massachusetts, United States
Recruiting
Va Ann Arbor Healthcare System, Ann Arbor, Mi
Ann Arbor, Michigan, United States
Recruiting
St. Louis Va Medical Center John Cochran Division, St. Louis, Mo
St Louis, Missouri, United States
Recruiting
Omaha Va Nebraska-Western Iowa Health Care System, Omaha, Ne
Omaha, Nebraska, United States
Recruiting
Va Ny Harbor Healthcare System, New York, Ny
New York, New York, United States
Recruiting
James J. Peters Va Medical Center, Bronx, Ny
The Bronx, New York, United States
Recruiting
Durham Va Medical Center, Durham, Nc
Durham, North Carolina, United States
Recruiting
Salisbury W.G. (bill) Hefner Va Medical Center, Salisbury, Nc
Salisbury, North Carolina, United States
Recruiting
Louis Stokes Va Medical Center, Cleveland, Oh
Cleveland, Ohio, United States
Recruiting
Va Portland Health Care System, Portland, Or
Portland, Oregon, United States
Recruiting
Corporal Michael J. Crescenz Va Medical Center, Philadelphia, Pa
Philadelphia, Pennsylvania, United States
Recruiting
Ralph H. Johnson Va Medical Center, Charleston, Sc
Charleston, South Carolina, United States
Recruiting
Wm. Jennings Bryan Dorn Va Medical Center, Columbia, Sc
Columbia, South Carolina, United States
Recruiting
Va North Texas Health Care System Dallas Va Medical Center, Dallas, Tx
Dallas, Texas, United States
Recruiting
Michael E. Debakey Va Medical Center, Houston, Tx
Houston, Texas, United States
Recruiting
Va Salt Lake City Health Care System, Salt Lake City, Ut
Salt Lake City, Utah, United States
Recruiting
Va Puget Sound Health Care System Seattle Division, Seattle, Wa
Seattle, Washington, United States
George N. Ioannou, MD MS
Recruiting
William S. Middleton Memorial Veterans Hospital, Madison, Wi
Madison, Wisconsin, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 3 Nov 2023
Primary completion: 1 Sept 2030
Completion: 1 Sept 2031
Last update posted: 17 Jun 2026
Registered enrollment: 4,700
Registry id: NCT05486572

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.