Clinical trialNCT05488431RecruitingPhase 2Interventional

Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)

SponsorPriscilla Hsue, MDEnrollment121AtherosclerosisCardiovascular DiseasesDyslipidemiasHIV Infections

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a randomized placebo-controlled study in treated and suppressed HIV-infected individuals aged ≥40 years with either known CVD or 1 CVD risk factor to study the effect of Bempedoic acid (BA) on safety, arterial inflammation as assessed by FDG-PET/CT, lipids, inflammation, immune activation, cardiometabolic indices, and non-calcified plaque (NCP) in the coronary arteries (assessed by coronary CT angiography, CCTA). This trial will be enrolled at UCSF and UCLA. Collaborators at Massachusetts General Hospital (MGH) will serve as the core facility for imaging.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Priscilla Hsue, MD
University of California, Los Angeles
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Ucla Center for Clinical Aids Research and Education (care)
Los Angeles, California, United States
Judith Currier, MDPriscilla Hsue, MD →
Recruiting
San Francisco General Hospital
San Francisco, California, United States
Adam Spivak, MDAhmed Tawakol, MDBorek Foldyna, MDJohn Kornak, MDMichael Lu, MDMiguel Pampaloni, MDPriscilla Hsue, MD →Steven Deeks, MDYoojin Lee, MD
Recruiting
Ut Health Houston
Houston, Texas, United States
Jordan Lake, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bempedoic acid →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Mar 2023
Primary completion: 1 Mar 2028
Completion: 1 Mar 2028
Last update posted: 17 Dec 2025
Registered enrollment: 121
Registry id: NCT05488431

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.