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Clinical trialNCT05496686Active, not recruitingPhase 1Interventional

Targeted Alpha Particle Radiotherapy for Metastatic Uveal Melanoma

SponsorModulation Therapeutics, Inc.Enrollment16MetastaticUveal Melanoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The primary aim of the study is to establish the maximum-tolerated dose (MTD) of 225Ac-MTI-201 in participants with metastatic uveal melanoma. The secondary aims are to describe the pharmacokinetics of 225Ac-MTI-201 and the toxic effects of 225Ac-MTI-201 in participants with metastatic uveal melanoma.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

1327 microCi of 225Ac-MTI-201152 microCi of 225Ac-MTI-20119 microCi of 225Ac-MTI-201254 microCi of 225Ac-MTI-20138 microCi of 225Ac-MTI-2014.7 microCi 225Ac-MTI-201424 microCi of 225Ac-MTI-201564 microCi of 225Ac-MTI-201750 microCi of 225Ac-MTI-20176 microCi of 225Ac-MTI-2019.5 microCi of 225Ac-MTI-201998 microCi of 225Ac-MTI-201
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
21 Jul 2022
Primary completion
31 Mar 2027
Completion
25 Feb 2029
Last update posted
3 Apr 2026
Registered enrollment
16
Registry id
NCT05496686

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.