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Clinical trialNCT05512208RecruitingPhase 2Interventional

A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib

SponsorUniversity of OklahomaEnrollment55Cervical CancerEndometrioid CancerHigh Grade Serous Ovarian CancerMucinous Ovarian CancerSolid Tumor
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this research is to test the effectiveness and safety of the study drugs (VS-6766 and defactinib), and see what effects (good and bad) these drugs have on the patients with endometrioid cancer, mucinous ovarian cancer, high-grade serous ovarian cancer, or solid gynecological cancer.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Adventhealth

    Orlando, Florida, United States

    Robert Holloway, MD
    Recruiting
  • Louisiana State University Medical Center New Orleans

    New Orleans, Louisiana, United States

    Tara Castellano, MD
    Recruiting
  • University of New Mexico Comprehensive Cancer Center

    Albuquerque, New Mexico, United States

    Carolyn C Muller, MD
    Recruiting
  • Stephenson Cancer Center

    Oklahoma City, Oklahoma, United States

    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AVUTOMETINIB/DEFACTINIB
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
6 Feb 2023
Primary completion
31 Dec 2027
Completion
31 Dec 2029
Last update posted
22 Oct 2025
Registered enrollment
55
Registry id
NCT05512208
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.