Clinical trialNCT05535166RecruitingPhase 2Interventional

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

SponsorSt. Jude Children's Research HospitalEnrollment130Medulloblastoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multi-center, multinational phase 2 trial that aims to explore the use of molecular and clinical risk-directed therapy in treatment of children 0-4.99 years of age with newly diagnosed medulloblastoma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Aditi Bagchi, MD, PhD
St. Jude Children's Research Hospital
Principal Investigator
clinicaltrials.gov ↗
Giles W. Robinson, MD
St. Jude Children's Research Hospital
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

10 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Lucille Packard Children'S Hospital Stanford
Palo Alto, California, United States
Sonia Partap, MD, MS,
Recruiting
Orlando Health Arnold Palmer Hospital for Children
Orlando, Florida, United States
Avery Wright, DO
Recruiting
St. Joseph'S Children'S Hospital
Tampa, Florida, United States
Trisha Larkin, MD
Recruiting
C.S. Mott Children'S Hospital, University of Michigan
Ann Arbor, Michigan, United States
Santhosh Upadhyaya, MD
Recruiting
Children'S Hospital and Clinics of Minnesota
Minneapolis, Minnesota, United States
Anne Bendel, MD
Recruiting
St. Jude Children'S Research Hospital
Memphis, Tennessee, United States
Aditi Bagchi, MD, PhDGiles W. Robinson, MD
Recruiting
Ut Southwestern Medical Center/harold C Simmons Comprehensive Cancer Center
Dallas, Texas, United States
Daniel Bowers, MD
Recruiting
Cook Children'S Medical Center
Fort Worth, Texas, United States
Sibo Zhao, MD
Recruiting
Texas Children'S Hospital
Houston, Texas, United States
Murali Chintagumpala, MD
Recruiting
Primary Children'S Hospital
Salt Lake City, Utah, United States
Nicholas Whipple, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Cisplatin →Cyclophosphamide →Etoposide →Filgrastim →Methotrexate →Pegfilgrastim →Topotecan →Vincristine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 20 Dec 2022
Primary completion: 31 Jul 2035
Completion: 31 Jul 2035
Last update posted: 12 Feb 2026
Registered enrollment: 130
Registry id: NCT05535166

Cross-registrations

Other registry (NCI Clinical Trial Registration ProgramNCI-2022-07099

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.