Clinical trialNCT05563766RecruitingPhase 2Interventional

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

SponsorVA Office of Research and DevelopmentEnrollment78Esophageal AdenocarcinomaEsophageal Squamous Cell CarcinomaGastroesophageal Junction Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Esophageal cancer, which has a low 5-year overall survival rate (\<20%) is increasing in incidence. Previous studies have shown that Hedgehog, AKT, and angiogenic signaling pathways are activated in a significant number of esophageal cancers. Itraconazole, a widely used anti-fungal medication, effectively inhibits these pathways. In this multi-site phase II trial, the investigators will evaluate the effect of itraconazole as a neoadjuvant therapy added to standard of care chemoradiation and surgery in the the treatment of locoregional esophageal and gastroesophageal junction cancers.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

David H Wang, MD PhD
VA Ann Arbor Healthcare System, Ann Arbor, MI
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Va Palo Alto Health Care System, Palo Alto, Ca
Palo Alto, California, United States
Recruiting
Va Ann Arbor Healthcare System, Ann Arbor, Mi
Ann Arbor, Michigan, United States
David H Wang, MD PhD
Recruiting
Durham Va Medical Center, Durham, Nc
Durham, North Carolina, United States
Recruiting
Va Portland Health Care System, Portland, Or
Portland, Oregon, United States
Recruiting
Va North Texas Health Care System Dallas Va Medical Center, Dallas, Tx
Dallas, Texas, United States
Recruiting
Michael E. Debakey Va Medical Center, Houston, Tx
Houston, Texas, United States
Recruiting
Va Puget Sound Health Care System Seattle Division, Seattle, Wa
Seattle, Washington, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Itraconazole →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Oct 2024
Primary completion: 30 Apr 2029
Completion: 15 Jun 2029
Last update posted: 5 Nov 2025
Registered enrollment: 78
Registry id: NCT05563766

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.