Clinical trialNCT05564377RecruitingPhase 2Interventional

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

SponsorNational Cancer Institute (NCI)Enrollment2,900Advanced Malignant Solid NeoplasmAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Locally Advanced Malignant Solid NeoplasmMalignant Female Reproductive System NeoplasmMetastatic HER2-Negative Breast Carcinoma+9 more conditions

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

James M Ford
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

481 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

Puerto Rico Hematology Oncology Group
Bayamón, Puerto Rico
Luis J. Santos Reyes
Recruiting
Doctors Cancer Center
Manati, Puerto Rico
Luis J. Santos Reyes
Recruiting
Centro Comprensivo de Cancer de Upr
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting
Proncology
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Rebecca C. Arend
Recruiting
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, United States
Ahmed Abdalla
Recruiting
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Ctca at Western Regional Medical Center
Goodyear, Arizona, United States
Sagun Shrestha
Recruiting
Kingman Regional Medical Center
Kingman, Arizona, United States
John A. Ellerton
Recruiting
Mayo Clinic Hospital in Arizona
Phoenix, Arizona, United States
Suspended
Nea Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States
Andrew J. Benefield
Recruiting
Pcr Oncology
Arroyo Grande, California, United States
John A. Ellerton
Recruiting
Mercy Cancer Center - Carmichael
Carmichael, California, United States
Shahzad Siddique
Recruiting
Mercy San Juan Medical Center
Carmichael, California, United States
Shahzad Siddique
Recruiting
Epic Care-Dublin
Dublin, California, United States
Active, not recruiting
Mercy Cancer Center - Elk Grove
Elk Grove, California, United States
Shahzad Siddique
Recruiting
Uc San Diego Health System - Encinitas
Encinitas, California, United States
Peter Vu
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
Peter Vu
Recruiting
Cedars-Sinai Medical Center
Los Angeles, California, United States
Omid Hamid
Recruiting
the Angeles Clinic and Research Institute - West Los Angeles Office
Los Angeles, California, United States
Omid Hamid
Recruiting
Contra Costa Regional Medical Center
Martinez, California, United States
Active, not recruiting
Children'S Hospital of Orange County
Orange, California, United States
Elyssa M. Rubin
Recruiting
Saint Joseph Hospital - Orange
Orange, California, United States
Timothy E. Byun
Recruiting
Stanford Cancer Institute Palo Alto
Palo Alto, California, United States
James M. Ford
Recruiting
Va Palo Alto Health Care System
Palo Alto, California, United States
Suspended
Mercy Cancer Center - Rocklin
Rocklin, California, United States
Shahzad Siddique
Recruiting
Mercy Cancer Center - Sacramento
Sacramento, California, United States
Shahzad Siddique
Recruiting
Sharp Memorial Hospital
San Diego, California, United States
Charles H. Redfern
Recruiting
Uc San Diego Medical Center - Hillcrest
San Diego, California, United States
Peter Vu
Recruiting
Ucsf Medical Center-Mission Bay
San Francisco, California, United States
Suspended
Saint John'S Cancer Institute
Santa Monica, California, United States
Reva K. Basho
Recruiting
Epic Care Cyberknife Center
Walnut Creek, California, United States
Active, not recruiting
Presbyterian Intercommunity Hospital
Whittier, California, United States
Suspended
Woodland Memorial Hospital
Woodland, California, United States
Shahzad Siddique
Recruiting
Uchealth University of Colorado Hospital
Aurora, Colorado, United States
Bradley R. Corr
Recruiting
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado, United States
Bradley R. Corr
Recruiting
Poudre Valley Hospital
Fort Collins, Colorado, United States
Bradley R. Corr
Recruiting
Uchealth Greeley Hospital
Greeley, Colorado, United States
Bradley R. Corr
Recruiting
Medical Center of the Rockies
Loveland, Colorado, United States
Bradley R. Corr
Recruiting
Helen F Graham Cancer Center
Newark, Delaware, United States
Gregory A. Masters
Recruiting

441 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Alpelisib →Binimetinib →Fluorouracil →Fulvestrant →Ipatasertib →Leucovorin →Neratinib →Nilotinib →Olaparib →Oxaliplatin →Paclitaxel →Palbociclib →Panitumumab →Selumetinib →Sotorasib →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 7 Apr 2023
Primary completion: 1 Jul 2030
Completion: 1 Jul 2030
Last update posted: 9 Jul 2026
Registered enrollment: 2,900
Registry id: NCT05564377

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.