Clinical trialNCT05574296RecruitingPhase 1Interventional

Hydrogen's Feasibility and Safety as a Therapy in ECPR

SponsorBoston Children's HospitalEnrollment53Cardiac ArrestExtracorporeal Membrane OxygenationReperfusion Injury

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e. mechanical circulatory support). Under exemption from informed consent, patients undergoing refractory cardiac arrest in the cardiac ICU at a participating center will be randomized to standard therapy with or without the administration of 2% hydrogen in gases administered via the ventilator and ECMO membrane for 72 hours.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

John N Kheir, MD
Associate Professor of Pediatrics, Harvard Medical School
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Children'S National Hospital
Washington D.C., District of Columbia, United States
Not, yet, recruiting
Boston Children'S Hospital
Boston, Massachusetts, United States
John Kheir, MDVictoria Habet, DO
Recruiting
Children'S Mercy Kansas City
Kansas City, Missouri, United States
Not, yet, recruiting
Primary Children'S Hospital
Salt Lake City, Utah, United States
Not, yet, recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Hydrogen

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 4 Mar 2024
Primary completion: 31 Mar 2027
Completion: 31 Aug 2027
Last update posted: 3 Jul 2025
Registered enrollment: 53
Registry id: NCT05574296

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.