Clinical trialNCT05580562RecruitingPhase 3Interventional

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

SponsorJazz PharmaceuticalsEnrollment510GliomaH3 K27M

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

162 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Fleni Neurologia
Buenos Aires, Argentina
Agustin Maximo Cardoso, MD
Recruiting

Australia

Sydney Children'S Hospital
Randwick, New South Wales, Australia
David Ziegler, BS, MB, MD
Recruiting
Royal North Shore Hospital
Sydney, New South Wales, Australia
Helen Wheeler, MD
Recruiting
Royal Brisbane and Women'S Hospital
Herston, Queensland, Australia
Zarnie Lwin, MD
Recruiting
Royal Hobart Hospital
Hobart, Tasmania, Australia
Thomas Walwyn
Recruiting
Olivia Newton-John Cancer Research Institute (onjcri)
Heidelberg, Victoria, Australia
Lawrence Cher
Recruiting
Perth Children'S Hospital
Nedlands, Western Australia, Australia
Santosh Valvi
Recruiting

Austria

Medical University of Vienna - Adults
Vienna, State of Vienna, Austria
Anna Bergmeister-Berghoff, MD
Recruiting
Medical University of Vienna - Pediatrics
Vienna, State of Vienna, Austria
Johannes Gojo
Recruiting

Brazil

Hcor Research Institute
São Paulo, Brazil
Gabriel Batistella
Recruiting
Hospital Do Graacc
São Paulo, Brazil
Andrea Maria Cappellano
Recruiting
Instituto Do Cancer Do Estado de São Paulo
São Paulo, Brazil
Olavo Feher, MD
Recruiting

Canada

Tom Baker Cancer Cetre
Calgary, Alberta, Canada
Paula De Robles, MD
Recruiting
Bc Cancer - the Vancouver Center
Vancouver, British Columbia, Canada
Rebecca Harrison, MD
Recruiting
Children'S & Women'S Health Care of Bc
Vancouver, British Columbia, Canada
George Michaiel
Recruiting
London Health Sciences Centre
London, Ontario, Canada
Seth Climans, MD
Recruiting
Childrens Hospital of Eastern Ontario
Ottawa, Ontario, Canada
Donna Johnston, MD
Recruiting
Princess Margaret Hospital
Toronto, Ontario, Canada
Julie Bennett, MD
Recruiting
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
Mary Lim-Fat, MD
Recruiting
Hopital Notre Dame, Lachapelle
Montreal, Quebec, Canada
Sarah Lapointe
Recruiting

Denmark

Copenhagen University Hospital
Copenhagen, Capital, Denmark
Søren Møller, MD
Recruiting
Aalborg Universitetshospital
Aalborg, North Denmark, Denmark
Charlotte Aaquist Haslund, MD
Recruiting
F345 H.C. Andersen'S Children'S Hospital
Odense, Region Syddanmark, Denmark
Michael Callesen
Recruiting
Odense Universitetshospital
Odense, Region Syddanmark, Denmark
Rikke Dahlrot, MD
Recruiting

Germany

University Clinic Heidelberg
Heidelberg, Baden-Wurttemberg, Germany
Cornelis van Tilburg, MD, PhD
Recruiting
Universitätsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, Germany
Antje Wick, MD
Recruiting
Universitätsklinikum Augsburg
Augsburg, Bavaria, Germany
Michael Frühwald, MD
Recruiting
University Clinic Regensburg
Regensburg, Bavaria, Germany
Peter Hau, MD
Recruiting
Klinikum Der Johann-Wolfgang Goethe-Universitat
Frankfurt am Main, Hesse, Germany
Michael Ronellenfitsch, MD
Recruiting
Universitätsklinikum Bonn
Bonn, North Rhine-Westphalia, Germany
Ulrich Herrlinger, MD
Recruiting
Uniklinik Köln
Cologne, North Rhine-Westphalia, Germany
Roland Goldbrunner, MD, PhD
Recruiting
Universitätsklinikum Essen
Essen, North Rhine-Westphalia, Germany
Sied Kebir
Recruiting
Vivantes Klinikum Neukölln
Berlin, Germany
Andreas Jödicke, MD
Recruiting
Klinikum Mannheim Universitätsklinikum Ggmbh
Manheim, Germany
Lukas Bunse, MD
Recruiting
Universitätsklinikum Tübingen
Tübingen, Germany
Ghazaleh Tabatabai, MD, PhD
Recruiting

Hong Kong

Queen Mary Hospital
Hong Kong, Hong Kong
Aya El Helali, MD
Recruiting

Israel

Sheba Medical Center
Ramat Gan, Tel Aviv, Israel
Michal Yalon, MD, PhD
Recruiting
Soroka University Medical Centre
Beersheba, Israel
Abed El Salem Abu Quider, MD
Recruiting
Rambam Medical Center
Haifa, Israel
Tali Siegal
Recruiting
Hadassah Ein Kerem Medical Center
Jerusalem, Israel
Alexander Lossos, MD
Recruiting

122 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 23 Jan 2023
Primary completion: 30 Jun 2028
Completion: 30 Jun 2028
Last update posted: 16 Apr 2026
Registered enrollment: 510
Registry id: NCT05580562

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.