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Clinical trialNCT05586776RecruitingPhase 4Interventional

Decolonization to Reduce After-Surgery Events of Surgical Site Infection

SponsorUniversity of California, IrvineEnrollment2,700Surgical Site Infection
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Hoag Memorial Hospital Presbyterian

    Newport Beach, California, United States

    Philip Robinson, MD
    Recruiting
  • University of California, Irvine Medical Center

    Orange, California, United States

    Susan Huang, MD, MPH →
    Recruiting
  • University of California, Davis Medical Center

    Sacramento, California, United States

    Stuart Cohen, MD
    Recruiting
  • University of California, San Francisco Medical Center

    San Francisco, California, United States

    Deborah Yokoe, MD, MPH
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

2% Mupirocin4% Chlorhexidine GluconatePlacebo Nasal OintmentSoap Without Antiseptic Properties
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
17 Jan 2023
Primary completion
30 Jun 2027
Completion
31 Dec 2027
Last update posted
21 Jul 2026
Registered enrollment
2,700
Registry id
NCT05586776
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.