Clinical trialNCT05595369CompletedPhase 2Interventional

RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms

SponsorKanecia Obie ZimmermanEnrollment963Long COVIDLong Covid19

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, double-blind, randomized, controlled platform trial with different interventions organized as appendices to the protocol. Each appendix (or sub-study) evaluates potential mechanisms of action, efficacy, and safety of antivirals and other therapeutics in individuals with PASC, according to the platform protocol objectives. The hypothesis is that persistent viral infection, viral reactivation, and/or overactive/chronic immune response and inflammation are underlying contributors to PASC and that antiviral and other applicable therapies may result in viral clearance or decreased inflammation and improvement in PASC symptoms.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Kanecia Zimmerman, MD PhD
Duke University
Study Chair
clinicaltrials.gov ↗
Richard Whitley, MD
University of Alabama at Birmingham Medical Center
Study ChairKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

69 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

Hispanic Alliance for Clinical and Translational Research, Univ of Puerto Rico
San Juan, Puerto Rico

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
University of Arizona/banner University Medical Center Phoenix
Phoenix, Arizona, United States
University of Arizona Banner Medical Center
Tucson, Arizona, United States
Cedars Sinai Medical Center
Los Angeles, California, United States
Hoag Memorial Hospital
Newport Beach, California, United States
University of California San Francisco General Hospital
San Francisco, California, United States
Stanford University
Stanford, California, United States
Los Angeles Biomedical Institute at Harbor-Ucla Medical Center
Torrance, California, United States
University of Colorado
Aurora, Colorado, United States
Howard University Hospital
Washington D.C., District of Columbia, United States
University of Florida College of Medicine Jacksonville
Jacksonville, Florida, United States
Lakeland Regional Medical Center
Lakeland, Florida, United States
Valencia Medical and Research Center
Miami, Florida, United States
Atlanta Va Medical Center
Atlanta, Georgia, United States
Grady Memorial Hospital
Atlanta, Georgia, United States
Kaiser Permanente Southwood
Atlanta, Georgia, United States
Morehouse School of Medicine
Atlanta, Georgia, United States
Emory Health Care
Decatur, Georgia, United States
Northwestern Memorial Hospital
Chicago, Illinois, United States
Rush University Medical Center
Chicago, Illinois, United States
University of Illinois at Chicago
Chicago, Illinois, United States
North Shore University Health System
Evanston, Illinois, United States
Koch Family Medicine
Morton, Illinois, United States
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Saint Francis Medical Center
Peoria, Illinois, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
University of Kentucky Chandler Medical Center
Lexington, Kentucky, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Jadestone Clinical Research, Llc
Silver Spring, Maryland, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Boston Medical Center
Boston, Massachusetts, United States
Brigham and Womens Hospital
Boston, Massachusetts, United States
Tufts Medical Center
Boston, Massachusetts, United States
Mayo Clinic
Rochester, Minnesota, United States
University of Mississippi Medical Center
Jackson, Mississippi, United States
Washington University School of Medicine
St Louis, Missouri, United States
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States
Rutgers University-Robert Wood Johnson Medical School
New Brunswick, New Jersey, United States
University of New Mexico Health Science Center
Albuquerque, New Mexico, United States

29 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Experimental: Paxlovid 15 day dosingExperimental: Paxlovid 25 day dosingPlacebo Comparator: Control

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 26 Jul 2023
Primary completion: 6 Aug 2024
Completion: 13 Mar 2025
Last update posted: 2 Dec 2025
Registered enrollment: 963
Registry id: NCT05595369

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.