Clinical trialNCT05617014Enrolling, by, invitationObservational

Alzheimer's Disease Neuroimaging Initiative 4

SponsorUniversity of Southern CaliforniaEnrollment1,500Alzheimer DiseaseDementiaMild Cognitive Impairment

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4) is a non-randomized, longitudinal, natural history study designed to validate biomarkers, improve clinical trial design, and advance understanding of Alzheimer's disease across the full disease spectrum. Building on the success of ADNI1, ADNI-GO, ADNI2, and ADNI3, ADNI4 integrates clinical, cognitive, imaging, genetic, and fluid biomarker data to characterize disease progression and predict cognitive decline. ADNI4 includes both in-clinic and remote cohorts and a small complementary sub-cohort, Together Exploring Aging Minds (TEAM-ADNI), which evaluates community-based recruitment and longitudinal data collection approaches.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Michael Weiner, MD
University of California, San Francisco
Study Director
clinicaltrials.gov ↗
Paul Aisen, MD
USC Alzheimer's Therapeutic Research Institute (ATRI)
Principal Investigator
clinicaltrials.gov ↗
Ronald Petersen, MD, PHD
Mayo Clinic
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

65 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Ubc Hospital Clinic for Alzheimer Disease and Related Disorders (card)
Vancouver, British Columbia, Canada
Parkwood Institute
London, Ontario, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
Banner Alzheimer'S Institute
Phoenix, Arizona, United States
Barrow Neurological Institute
Phoenix, Arizona, United States
Banner Sun Health Research Institute
Sun City, Arizona, United States
University of California, Irvine
Irvine, California, United States
University of California, San Diego
La Jolla, California, United States
University of California, Los Angeles
Los Angeles, California, United States
University of Southern California
Los Angeles, California, United States
Stanford University
Palo Alto, California, United States
University of California, San Francisco
San Francisco, California, United States
University of California, Davis
Walnut Creek, California, United States
Yale University
New Haven, Connecticut, United States
Georgetown University
Washington D.C., District of Columbia, United States
Howard University
Washington D.C., District of Columbia, United States
University of Florida
Gainesville, Florida, United States
Mayo Clinic, Jacksonville
Jacksonville, Florida, United States
Gonzalez Md & Aswad Md Health Services
Miami, Florida, United States
Wien Center
Miami Beach, Florida, United States
Charter Research
Orlando, Florida, United States
University of South Florida Health Byrd Alzheimer'S Institute
Tampa, Florida, United States
Emory University
Atlanta, Georgia, United States
Alliancechicago
Chicago, Illinois, United States
Northwestern University
Chicago, Illinois, United States
Rush University Memory Clinic
Chicago, Illinois, United States
University of Chicago
Chicago, Illinois, United States
Indiana University
Indianapolis, Indiana, United States
University of Iowa
Iowa City, Iowa, United States
University of Kansas
Fairway, Kansas, United States
University of Kentucky
Lexington, Kentucky, United States
Johns Hopkins University
Baltimore, Maryland, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Boston University
Boston, Massachusetts, United States
Brigham and Women'S Hospital
Boston, Massachusetts, United States
the Fenway Institute - Fenway Health
Boston, Massachusetts, United States
University of Michigan, Ann Arbor
Ann Arbor, Michigan, United States
Mayo Clinic Alzheimer'S Disease Research Center
Rochester, Minnesota, United States
Washington University, St Louis
St Louis, Missouri, United States

25 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 9 Jun 2023
Primary completion: 31 Jul 2027
Completion: 31 Jul 2027
Last update posted: 14 Aug 2026
Registered enrollment: 1,500
Registry id: NCT05617014

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.