Clinical trialNCT05641688RecruitingPhase 3Interventional

[18F]PI-2620 Phase 3 Histopathological Study

SponsorLantheus Biosciences Ltd.Enrollment200Alzheimer Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is an open-label, multi-center, non-randomized pivotal Phase 3 study to assess the efficacy and safety of PET imaging with \[18F\]PI-2620 for detection of tau deposition in subjects with Alzheimer's disease (AD) and controls during lifetime when compared to histopathology obtained after death and completion of brain autopsy.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Alireza Atri, MD, PhD
Banner Health
Principal Investigator
clinicaltrials.gov ↗
Andrew Stephens, MD, PhD
Life Molecular Imaging
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

25 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Barrow Neurological Institute
Phoenix, Arizona, United States
Recruiting
Banner Sun Health Research Institute
Sun City, Arizona, United States
Recruiting
Uc Los Angeles
Los Angeles, California, United States
Recruiting
Esperanza Clinical
Murrieta, California, United States
Recruiting
Sutter Health
San Francisco, California, United States
Recruiting
Galiz Research
Hialeah, Florida, United States
Recruiting
Uf College of Medicine - Jacksonville
Jacksonville, Florida, United States
Withdrawn
K2 Medical Research
Lady Lake, Florida, United States
Recruiting
K2 Medical Research
Maitland, Florida, United States
Recruiting
Clincloud Research
Melbourne, Florida, United States
Recruiting
Miami Jewish Health Systems
Miami, Florida, United States
Recruiting
the Roskamp Institute
Sarasota, Florida, United States
Terminated
Charter Research
Winter Park, Florida, United States
Recruiting
Alzheimer'S Disease Center
Braintree, Massachusetts, United States
Recruiting
Headlands Research
Plymouth, Massachusetts, United States
Withdrawn
Be Well Clinical Studies
Lincoln, Nebraska, United States
Withdrawn
Darthmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States
Recruiting
Velocity Clinical Research
East Syracuse, New York, United States
Recruiting
Ichor Research
Syracuse, New York, United States
Recruiting
American Carolina Clinical Research Llc
Charlotte, North Carolina, United States
Terminated
Insight Clinical Trials Llc
Beachwood, Ohio, United States
Recruiting
Valley Medical Research
Centerville, Ohio, United States
Recruiting
Baylor Research Institute
Dallas, Texas, United States
Recruiting
Sante Clinical Research
Kerrville, Texas, United States
Recruiting
Be Well Clinical Studies
Round Rock, Texas, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

[18F]PI-2620

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Dec 2022
Primary completion: 30 Jun 2027
Completion: 30 Jun 2027
Last update posted: 22 May 2026
Registered enrollment: 200
Registry id: NCT05641688

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.