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Clinical trialNCT05673187Active, not recruitingPhase 2Interventional

Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance Status

SponsorETOP IBCSG Partners FoundationEnrollment68KRAS P.G12CNSCLC Stage IV
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

ADEPPT is an international, multicentre, single-arm phase II trial. The protocol treatment consists of adagrasib, which is administered at a dose of 600 mg orally, twice daily until progression or unacceptable toxicity.The primary objective of this trial is to assess the clinical efficacy of adagrasib treatment, in terms of objective response, in patients with KRASG12C-mutant NSCLC, including the elderly (≥70 years) or patients with poor performance status (ECOG PS=2).

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

18 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Belgium
  • Instiute Jules Bordet

    Brussels, Belgium

France
  • Le Mans - Chg

    Le Mans, France

  • Hôpital de Marseille

    Marseille, France

Ireland
  • Beaumont Hospital

    Dublin, Ireland

  • University Hospital Limerick

    Limerick, Ireland

  • University Hospital Waterford

    Waterford, Ireland

Italy
  • Santa Maria Della Misericordia Hospital

    Perugia, Italy

  • Istituto Nazionale Tumori "regina Elena"

    Rome, Italy

  • Aulss2 Marca Trevigiana Treviso

    Treviso, Italy

Spain
  • Complejo Hospitalario Universitario A Coruña

    A Coruña, Spain

  • Alicante University Hospital

    Alicante, Spain

  • Ico Badalona - Hospital Germans Trias I Pujol

    Badalona, Spain

  • Hospital de Basurto

    Bilbao, Spain

  • Ico Bellvitge -H. Duran I Reynals / H. Bellvitge

    L'Hospitalet de Llobregat, Spain

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, Spain

  • Hospital Universitario Puerta de Hierro

    Madrid, Spain

  • Hospital General Universitario de Valencia (university Hospital Valencia)

    Valencia, Spain

United Kingdom
  • Christie Nhs Manchester

    Manchester, United Kingdom

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
12 Jun 2023
Primary completion
28 Jul 2025
Completion
31 Dec 2026
Last update posted
3 Sept 2026
Registered enrollment
68
Registry id
NCT05673187

Cross-registrations

EU-CTR / CTIS (EudraCT)2022-002736-31

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.