FindMyKOL
Clinical trialNCT05686226RecruitingPhase 2Interventional

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

SponsorChristian HinrichsEnrollment20Anal CancerCervical CancerHPV Positive Oropharyngeal Squamous Cell CarcinomaHPV Positive Rectal Squamous Cell CarcinomaHPV-Associated Vaginal AdenocarcinomaHPV-Related Adenocarcinoma+15 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a phase II clinical trial to assess the clinical activity of immunotherapy with E7 TCR-T cells for metastatic HPV-associated cancers. HPV-associated cancers in include cervical, throat, penile, vulvar, vaginal, anal, and other cancers. Participants will receive a conditioning regimen, E7 TCR-T cells, and aldesleukin. Clinical response to treatment will be determined.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • National Institutes of Health Clinical Center

    Bethesda, Maryland, United States

    Scott M Norberg, DO
    Recruiting
  • Rwjbarnabas Health - Robert Wood Johnson University Hospital

    New Brunswick, New Jersey, United States

    Recruiting
  • Rutgers Cancer Institute

    New Brunswick, New Jersey, United States

    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Aldesleukin →E7 TCR-T cells
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
7 Mar 2023
Primary completion
1 Jan 2027
Completion
1 Jan 2027
Last update posted
12 Jun 2026
Registered enrollment
20
Registry id
NCT05686226
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.