Clinical trialNCT05701917RecruitingInterventional

DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis

SponsorInari MedicalEnrollment300Deep Venous ThrombosisPost-Thrombotic SyndromeVenous Thromboembolism

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of subjects with symptomatic unilateral iliofemoral DVT. The study will collect data on demographics, comorbidities, details from the DVT diagnosis and treatment, and clinical outcomes through the 6-month follow up visit.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Stephen Black, MD
St Thomas' Hospital (UK)
Principal Investigator
clinicaltrials.gov ↗
Steven Abramowitz, MD
MedStar Health Research Institution
Principal Investigator
clinicaltrials.gov ↗
Xhorlina Marko, MD
Henry Ford Health
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

64 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Austria

Vienna General Hospital (akh Wien)
Vienna, Austria
Recruiting

Finland

Helsinki University Hospital
Helsinki, Finland
Recruiting

Germany

Universitätsklinikum Tübingen
Tübingen, Baden-Würtemberg, Germany
Recruiting
Mvz Ccb Frankfurt Und Main-Taunus Gbr
Frankfurt am Main, Hesse, Germany
Recruiting
Klinikum Hochsauerland Gmbh
Arnsberg, North Rhine-Westphalia, Germany
Recruiting
Universität Leipzig
Leipzig, Saxony, Germany
Recruiting
Charité - Universitätsmedizin Berlin
Berlin, State of Berlin, Germany
Terminated
Universitätsklinikum Augsburg
Augsburg, Germany
Recruiting
Universitätsklinikum Heidelberg
Heidelberg, Germany
Recruiting

Switzerland

Kantonsspital Baden
Baden, Switzerland
Recruiting
Inselspital, Universitätsspital Bern
Bern, Switzerland
Recruiting
Luzerner Kantonsspital
Lucerne, Switzerland
Recruiting

United Kingdom

Gsst London/st Thomas
London, United Kingdom
Recruiting
Imperial College
London, United Kingdom
Recruiting
Freeman Hospital Newcastle Upon Tyne
Newcastle upon Tyne, United Kingdom
Recruiting
Oxford - John Radcliffe
Oxford, United Kingdom
Recruiting

United States

Honor Health
Scottsdale, Arizona, United States
Recruiting
Pima Heart and Vascular
Tucson, Arizona, United States
Recruiting
Uci Medical Center
Orange, California, United States
Recruiting
Vascular and Interventional Specialists of Orange County
Orange, California, United States
Recruiting
Huntington Health
Pasadena, California, United States
Recruiting
University of Colorado
Denver, Colorado, United States
Recruiting
Yale University
New Haven, Connecticut, United States
Recruiting
Medstar Health Research Institution
Washington D.C., District of Columbia, United States
Recruiting
Manatee Memorial Hospital
Bradenton, Florida, United States
Terminated
Baptist Health Research Institute
Jacksonville, Florida, United States
Recruiting
Lakeland Vascular Institute
Lakeland, Florida, United States
Terminated
Hca Florida Largo Hospital
Largo, Florida, United States
Terminated
Sarasota Memorial Hospital
Sarasota, Florida, United States
Recruiting
Baycare Health System
Tampa, Florida, United States
Recruiting
Memorial Health University Medical Center
Savannah, Georgia, United States
Terminated
Community Healthcare System
Munster, Indiana, United States
Terminated
St. Elizabeth Edgewood
Edgewood, Kentucky, United States
Terminated
University of Maryland
Baltimore, Maryland, United States
Recruiting
Mclaren Healthcare
Bay City, Michigan, United States
Recruiting
Henry Ford Health
Detroit, Michigan, United States
Recruiting
Mymichigan Medical Center
Midland, Michigan, United States
Recruiting
University of Missouri
Columbia, Missouri, United States
Recruiting
Saint Luke'S Hospital of Kansas City
Kansas City, Missouri, United States
Terminated
St. Louis University
St Louis, Missouri, United States
Recruiting

24 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 6 Jan 2023
Primary completion: 31 Jan 2028
Completion: 31 Jul 2028
Last update posted: 18 Aug 2026
Registered enrollment: 300
Registry id: NCT05701917

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.