Clinical trialNCT05705024RecruitingPhase 2Interventional

Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells

SponsorUniversity of Illinois at ChicagoEnrollment38Corneal Ulcer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The proposed Conventional Cohort Expansion Study involves the use of Mesenchymal Stromal Cells (MSCs) are derived from the bone marrow. We previously studied the safety of subconjunctival injection of allogeneic bone marrow-derived MSCs in patients with nonhealing epitheliopathy (IRB Protocol 2020-0334). In the present study, we want to study the efficacy of this treatment on chronic epitheliopathies.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Ali R Djalilian, MD
University of Illinois at Chicago
Principal Investigator
clinicaltrials.gov ↗
Charlotte E Joslin, OD, PhD
University of Illinois at Chicago
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Department of Ophthalmology and Visual Sciences
Chicago, Illinois, United States
Recruiting
University of Maryland at Baltimore
Baltimore, Maryland, United States
Sarah Sunshine, MD
Recruiting
Mass Eye and Ear Infirmary
Boston, Massachusetts, United States
Active, not recruiting
University of Pennsylvania, Scheie Eye Institute
Philadelphia, Pennsylvania, United States
Active, not recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Human Umbilical Cord Mesenchymal Stem Cells

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Sept 2023
Primary completion: 28 Sept 2026
Completion: 28 Sept 2026
Last update posted: 16 Dec 2025
Registered enrollment: 38
Registry id: NCT05705024

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.