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Clinical trialNCT05714839RecruitingPhase 1/PHASE2Interventional

A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments

SponsorGlaxoSmithKlineEnrollment123Multiple Myeloma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The study consists of three parts: * Part 1: The primary purpose of this part aims to evaluate the safety, tolerability, and clinical activity of escalating doses of single agent belantamab in participants with refractory multiple myeloma (RRMM) who have received at least 3 prior therapies (4L+). * Part 2: The primary purpose of this part is to evaluate the safety, tolerability, and clinical activity of different doses of belantamab in combination with a fixed dose of Belantamab mafodotin (delivered as separate drugs) in participants with RRMM who have received at least 3 prior therapies (4L+). * Part 3: The Primary purpose of this part will evaluate the clinical activity of a selected dose of the belantamab in combination with the pomalidomide-dexamethasone (Pd) standard of care (SoC) backbone. The study will focus on participants with multiple myeloma who have undergone at least one prior line of therapy, including treatment with lenalidomide.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

44 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina
  • Gsk Investigational Site

    Capital Federal, Argentina

    Paola Ochoa
    Recruiting
  • Gsk Investigational Site

    Ciudadela, Argentina

    Completed
  • Gsk Investigational Site

    Rosario, Argentina

    Herman Perroud
    Recruiting
  • Gsk Investigational Site

    San Juan Bautista, Argentina

    Maria Julieta Dalmaroni
    Recruiting
  • Gsk Investigational Site

    Viedma, Argentina

    Rubén Kowalyszyn
    Recruiting
Australia
  • Gsk Investigational Site

    Fitzroy, Victoria, Australia

    Hang Quach
    Recruiting
  • Gsk Investigational Site

    Nedlands, Western Australia, Australia

    Completed
Brazil
  • Gsk Investigational Site

    Joinville, Brazil

    Marcelo Pitombeira de Lacerda
    Recruiting
  • Gsk Investigational Site

    Salvador, Brazil

    Edvan de Queiroz Crusoe
    Recruiting
  • Gsk Investigational Site

    São Paulo, Brazil

    Vania Hungria
    Recruiting
China
  • Gsk Investigational Site

    Suzhou, China

    Chengcheng Fu
    Recruiting
Israel
  • Gsk Investigational Site

    Beersheba, Israel

    Miri Zekster
    Recruiting
  • Gsk Investigational Site

    Jerusalem, Israel

    moshe gatt
    Recruiting
  • Gsk Investigational Site

    Ramat Gan, Israel

    Eli Muchtar
    Recruiting
Japan
  • Gsk Investigational Site

    Aomori, Japan

    Tomoaki Akagi
    Recruiting
  • Gsk Investigational Site

    Chiba, Japan

    Junichiro Yuda
    Recruiting
  • Gsk Investigational Site

    Kanagawa, Japan

    Tomonori Nakazato
    Recruiting
  • Gsk Investigational Site

    Osaka, Japan

    Completed
  • Gsk Investigational Site

    Tokyo, Japan

    Kazuhito Suzuki
    Recruiting
  • Gsk Investigational Site

    Yamagata, Japan

    satoshi ito
    Recruiting
Poland
  • Gsk Investigational Site

    Gdansk, Poland

    Withdrawn
  • Gsk Investigational Site

    Lublin, Poland

    Marek Hus
    Recruiting
South Africa
  • Gsk Investigational Site

    Kuils River, Western Cape, South Africa

    Michael Cass
    Recruiting
South Korea
  • Gsk Investigational Site

    Seoul, South Korea

    chang-ki min
    Recruiting
  • Gsk Investigational Site

    Seoul, South Korea

    Dok Hyun Yoon
    Recruiting
Taiwan
  • Gsk Investigational Site

    Changhua, Taiwan

    Hsuan-Yu Lin
    Recruiting
  • Gsk Investigational Site

    Kaohsiung City, Taiwan

    Shih-Feng Cho
    Recruiting
  • Gsk Investigational Site

    Taipei, Taiwan

    SHANG YI Huang
    Recruiting
Turkey (Türkiye)
  • Gsk Investigational Site

    Istanbul, Turkey (Türkiye)

    SINEM BOZDAG
    Recruiting
  • Gsk Investigational Site

    Kayseri, Turkey (Türkiye)

    Neslihan Mandaci sanli
    Recruiting
United Kingdom
  • Gsk Investigational Site

    Leicester, United Kingdom

    Linda Barton
    Recruiting
  • Gsk Investigational Site

    Oxford, United Kingdom

    Completed
  • Gsk Investigational Site

    Plymouth, United Kingdom

    Hannah Hunter
    Recruiting
United States
  • Gsk Investigational Site

    Bullhead City, Arizona, United States

    Hamdy Mohtaseb
    Recruiting
  • Gsk Investigational Site

    Los Angeles, California, United States

    Ghassan Al-Jazayrly
    Recruiting
  • Gsk Investigational Site

    Pembroke Pines, Florida, United States

    Isaac Levy
    Recruiting
  • Gsk Investigational Site

    Boston, Massachusetts, United States

    Paul Richardson
    Recruiting
  • Gsk Investigational Site

    Grand Rapids, Michigan, United States

    Andrew Sochacki
    Recruiting
  • Gsk Investigational Site

    Chapel Hill, North Carolina, United States

    Eben Lichtman
    Recruiting
  • Gsk Investigational Site

    Wilson, North Carolina, United States

    Keith Lerro
    Recruiting
4 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
14 Jun 2023
Primary completion
3 Aug 2028
Completion
3 Aug 2028
Last update posted
19 Aug 2026
Registered enrollment
123
Registry id
NCT05714839

Cross-registrations

EU-CTR / CTIS (EudraCT)2022-501941-63-00

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.