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Clinical trialNCT05721755Active, not recruitingPhase 3Interventional

Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck

SponsorECOG-ACRIN Cancer Research GroupEnrollment290Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Metastatic Head and Neck Squamous Cell CarcinomaMetastatic Hypopharyngeal Squamous Cell CarcinomaMetastatic Laryngeal Squamous Cell CarcinomaMetastatic Oral Cavity Squamous Cell CarcinomaMetastatic Oropharyngeal Squamous Cell Carcinoma+5 more conditions
View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

51 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Moffitt Cancer Center

    Tampa, Florida, United States

  • Moffitt Cancer Center - Mckinley Campus

    Tampa, Florida, United States

  • Moffitt Cancer Center-International Plaza

    Tampa, Florida, United States

  • Emory University Hospital Midtown

    Atlanta, Georgia, United States

  • Saint Luke'S Cancer Institute - Boise

    Boise, Idaho, United States

  • Saint Luke'S Cancer Institute - Fruitland

    Fruitland, Idaho, United States

  • Saint Luke'S Cancer Institute - Meridian

    Meridian, Idaho, United States

  • Saint Luke'S Cancer Institute - Nampa

    Nampa, Idaho, United States

  • Saint Luke'S Cancer Institute - Twin Falls

    Twin Falls, Idaho, United States

  • University of Illinois

    Chicago, Illinois, United States

  • Carle at the Riverfront

    Danville, Illinois, United States

  • Carle Physician Group-Effingham

    Effingham, Illinois, United States

  • Carle Physician Group-Mattoon/charleston

    Mattoon, Illinois, United States

  • Carle Cancer Center

    Urbana, Illinois, United States

  • Mission Cancer and Blood - Ankeny

    Ankeny, Iowa, United States

  • Mercy Hospital

    Cedar Rapids, Iowa, United States

  • Oncology Associates at Mercy Medical Center

    Cedar Rapids, Iowa, United States

  • Iowa Methodist Medical Center

    Des Moines, Iowa, United States

  • Mission Cancer and Blood - Des Moines

    Des Moines, Iowa, United States

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota, United States

  • Freeman Health System

    Joplin, Missouri, United States

  • Sands Cancer Center

    Canandiaqua, New York, United States

  • Highland Hospital

    Rochester, New York, United States

  • University of Rochester

    Rochester, New York, United States

  • Wilmot Cancer Institute Radiation Oncology at Greece

    Rochester, New York, United States

  • Stony Brook University Medical Center

    Stony Brook, New York, United States

  • Wilmot Cancer Institute at Webster

    Webster, New York, United States

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota, United States

  • Sanford Broadway Medical Center

    Fargo, North Dakota, United States

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota, United States

  • Uh Seidman Cancer Center at Uh Avon Health Center

    Avon, Ohio, United States

  • Case Western Reserve University

    Cleveland, Ohio, United States

  • Uh Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, United States

  • Providence Newberg Medical Center

    Newberg, Oregon, United States

  • Providence Saint Vincent Medical Center

    Portland, Oregon, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, United States

  • Medical University of South Carolina

    Charleston, South Carolina, United States

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota, United States

  • Sanford Usd Medical Center - Sioux Falls

    Sioux Falls, South Dakota, United States

11 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
8 Jun 2023
Primary completion
31 Mar 2029
Completion
31 Mar 2030
Last update posted
10 Jul 2026
Registered enrollment
290
Registry id
NCT05721755

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.