Clinical trialNCT05722002RecruitingPhase 4Interventional

Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

SponsorUniversity of MichiganEnrollment900Pain, PostoperativeSurgery

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is anticipated that the NSAID group will have superior clinical outcomes and fewer side effects when compared to the opioid group.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Mark Bicket, MD, PhD
University of Michigan
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Unity Health Toronto
Toronto, Ontario, Canada
Duminda Wijeysundera, MD, PhD
Recruiting
Women'S College Hospital
Toronto, Ontario, Canada
Karim Ladha, MD, MSc, AB, FRCPC
Recruiting

United States

University of Michigan
Ann Arbor, Michigan, United States
Mark Bicket, MD, PhD
Recruiting
Henry Ford Health System
Detroit, Michigan, United States
Kellie McFarlin, MD, FACS
Recruiting
Washington University in Saint Louis
St Louis, Missouri, United States
Simon Haroutounian, PhD, MSc
Recruiting
Cooper University Health Care
Camden, New Jersey, United States
Ludmil Mitrev, MD
Recruiting
University of North Carolina Hospitals
Chapel Hill, North Carolina, United States
Matthew Mauck, MD, PhD
Recruiting
Temple University - Temple Health
Philadelphia, Pennsylvania, United States
Ellen Hauck, DO
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Acetaminophen →NSAIDOpioid

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 6 Feb 2023
Primary completion: 10 Feb 2027
Completion: 31 Aug 2027
Last update posted: 28 Aug 2026
Registered enrollment: 900
Registry id: NCT05722002

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.