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Clinical trialNCT05743270WithdrawnPhase 2Interventional

Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN

SponsorReplimune, Inc.Enrollment0Locally Advanced Head and Neck Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell CarcinomaSquamous Cell Carcinoma of Head and Neck
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a Phase 2, multicenter, open-label, 2-cohort (Locoregionally Advanced Cohort or Recurrent/Metastatic Cohort) study evaluating RP3 in combination with concurrent chemoradiation therapy (CCRT) followed by nivolumab (for the LA Cohort) or combined with chemotherapy and nivolumab (for the R/M Cohort) in patients with advanced, inoperable squamous cell carcinomas of the head and neck (SCCHN), including of the oral cavity, oropharynx, hypopharynx, larynx, or unknown primary.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

34 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Czechia
  • University Hospital Olomouc

    Olomouc, Czechia

  • Fn Kralovske Vinohrady

    Prague, Czechia

  • Fakultni Thomayerova Nemocnice

    Prague, Czechia

France
  • Centre Georges Francois Leclerc, Department of Oncology

    Dijon, France

  • Centre Leon Berard

    Lyon, France

  • Assistance Publique Hopitaux de Marseille

    Marseille, France

  • Chu Nimes, Instiut de Cancerologie Du Gard, Medical Oncology

    Nîmes, France

  • Institut Gustave Roussy Paris

    Villejuif, France

Germany
  • Charite University Hospital of Berlin, Comprehensive Cancer Center

    Berlin, Germany

  • Universitatsklinik Jena Klinik Und Poliklinik Fur Hals-, Nasen - Und Ohrenheilkunde

    Jena, Germany

  • University Hospital Leipzig Clinic and Polyclinic for Otorhinolaryngology

    Leipzig, Germany

  • Lmu Klinikum, Medizinische Klinik Und Poliklinikum Iii

    Munich, Germany

  • Universitatsklinikum Ulm

    Ulm, Germany

Greece
  • University General Hospital Attikon

    Chaïdári, Greece

  • Agios Lukas Hospital

    Thessaloniki, Greece

Poland
  • Szpital Specjalistyczny Im Ludwika Rydygiera W Krakowie Sp Z Oo, Department of Clinical Oncology

    Krakow, Poland

Spain
  • Vall D'Hebron University Hospital, Vall D' Hebron Institute of Oncology (vhio)

    Barcelona, Spain

  • Hospital Universitario Hm Sanchinarro

    Madrid, Spain

  • la Paz Univeristy Hospital, Universidad Autonoma de Madrid

    Madrid, Spain

  • Clinica Universitaria de Navarra

    Pamplona, Spain

  • Fundacion Instituto Valenciano de Oncologia

    Valencia, Spain

United Kingdom
  • the Royal Marsden Nhs Foundation Trust

    London, United Kingdom

United States
  • University of California San Diego, Ucsd

    La Jolla, California, United States

  • Ucla Medicine Division of Hematology-Oncology

    Los Angeles, California, United States

  • Usc Norris Comprehensive Cancer Center

    Los Angeles, California, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, United States

  • University of Cincinnati Medical Center

    Cincinnati, Ohio, United States

  • Cleveland Clinic

    Cleveland, Ohio, United States

  • Thomas Jefferson University City Center and Abington

    Philadelphia, Pennsylvania, United States

  • University of Pittsburgh Medical Center, Upmc

    Pittsburgh, Pennsylvania, United States

  • Jefferson Health Abington Asplunhd Cancer Pavillion

    Willow Grove, Pennsylvania, United States

  • Sarah Cannon Research Institute

    Nashville, Tennessee, United States

  • University of Washington / Fred Hutchinson Cancer Center

    Seattle, Washington, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

RP3Nivolumab
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Jan 2024
Primary completion
1 Mar 2026
Completion
1 Jun 2026
Last update posted
11 Mar 2025
Registered enrollment
0
Registry id
NCT05743270

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.