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Clinical trialNCT05763251RecruitingInterventional

Comparison of Uncomplicated Candidemia Therapy Duration in Children

SponsorArkansas Children's Hospital Research InstituteEnrollment420Invasive Candidiasis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this clinical trial is to compare antifungal therapy duration in pediatric uncomplicated candidemia. The specific aims are: * Compare the desirability of outcome ranking in children with uncomplicated candidemia randomized to 7 additional days of antifungal therapy (standard-course) versus no additional antifungal therapy (short-course) after already receiving 7 days of echinocandin therapy. * Compare the 14-day desirability of outcome measure for subjects with a negative and those with a positive T2Candida® biomarker at day 7 of therapy within randomized groups. Participants meeting eligibility criteria will be approached and consented between day 5 and 7 of primary systemic antifungal therapy. On day 7 of primary systemic antifungal therapy, inclusion and exclusion criteria will again be reviewed for consented patients and those still eligible will be randomized 1:1 to the two study arms. Researchers will compare no additional antifungal therapy (short-course) versus 7 additional days of systemic antifungal therapy (standard-course) in pediatric patients with uncomplicated candidemia who have already received 7 days of primary systemic antifungal therapy to see if shorter durations are as effective as longer durations in treating uncomplicated candidemia.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

22 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Perth Children'S Hospital

    Perth, Western Australia, Australia

    Recruiting
United States
  • Children'S Hospital of Alabama

    Birmingham, Alabama, United States

    Recruiting
  • Arkansas Children'S Hospital

    Little Rock, Arkansas, United States

    Recruiting
  • Children'S Hospital of Orange County

    Orange, California, United States

    Recruiting
  • Yale New Haven Children'S Hospital

    New Haven, Connecticut, United States

    Recruiting
  • Children'S Healthcare of Atlanta

    Atlanta, Georgia, United States

    Recruiting
  • Comer Children'S Hospital

    Chicago, Illinois, United States

    Recruiting
  • Lurie Children'S Hospital of Chicago

    Chicago, Illinois, United States

    Recruiting
  • Riley Children'S Hospital

    Indianapolis, Indiana, United States

    Recruiting
  • Boston Children'S Hospital

    Boston, Massachusetts, United States

    Recruiting
  • Cs Mott Children'S Hospital

    Ann Arbor, Michigan, United States

    Recruiting
  • Washington University St. Louis

    St Louis, Missouri, United States

    Recruiting
  • University of Nebraska Medical Center

    Omaha, Nebraska, United States

    Recruiting
  • Weill Cornell Medical College

    New York, New York, United States

    Recruiting
  • Duke Children'S Hospital

    Durham, North Carolina, United States

    Recruiting
  • Cincinnati Children'S Hospital

    Cincinnati, Ohio, United States

    Recruiting
  • Nationwide Children'S Hospital

    Columbus, Ohio, United States

    Recruiting
  • Children'S Hospital of Philadelphia

    Philadelphia, Pennsylvania, United States

    Recruiting
  • Dell Children'S Medical Center

    Austin, Texas, United States

    Recruiting
  • University of Texas Southwestern Medical Center

    Dallas, Texas, United States

    Recruiting
  • Primary Children'S Hospital

    Salt Lake City, Utah, United States

    Recruiting
  • Children'S Hospital of Wisconsin

    Milwaukee, Wisconsin, United States

    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
8 Sept 2023
Primary completion
30 Jun 2030
Completion
30 Jun 2032
Last update posted
17 Apr 2026
Registered enrollment
420
Registry id
NCT05763251

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.