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Clinical trialNCT05772546Active, not recruitingPhase 2Interventional

Avatrombopag vs. Placebo for CIT in GI Malignancies

SponsorHanny Al-Samkari, MDEnrollment60Chemotherapy-Induced ThrombocytopeniaGastrointestinal CancerGastrointestinal Neoplasms
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to compare the efficacy of two study drugs, Avatrobopag versus placebo, to treat persistent Chemotherapy-Induced Thrombocytopenia (CIT) in patients with gastrointestinal (GI) malignancies receiving cytotoxic chemotherapy. The names of the study drugs involved in this study are: * Avatrombopag (a thrombopoietin receptor agonist) * Matching placebo
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Miami Sylvester Comprehensive Cancer Center

    Miami, Florida, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, United States

  • Oregon Health and Science University Hospital

    Portland, Oregon, United States

  • University of Washington Fred Hutchinson Cancer Center

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Avatrombopag →Matching Placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
1 Nov 2023
Primary completion
2 Jan 2026
Completion
31 Jul 2026
Last update posted
13 Mar 2026
Registered enrollment
60
Registry id
NCT05772546
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.