Clinical trialNCT05806515RecruitingPhase 2Interventional

Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

SponsorSWOG Cancer Research NetworkEnrollment44Prostate AdenocarcinomaStage IIIB Prostate Cancer AJCC v8Stage IIIC Prostate Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial tests how well carboplatin before surgery works in treating patients with high-risk prostate cancer and an inherited BRCA1 or BRCA2 gene mutation. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowing the growth of tumor cells. Giving carboplatin before surgery may shrink tumors in patients with high-risk prostate cancer with BRCA1 and BRCA2 gene mutations.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Heather H Cheng
SWOG Cancer Research Network
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

133 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Alaska Breast Care and Surgery Llc
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Anchorage Oncology Centre
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Anchorage Radiation Therapy Center
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Katmai Oncology Group
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Cancer Center at Saint Joseph'S
Phoenix, Arizona, United States
Shahzad Siddique
Recruiting
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, United States
Shahzad Siddique
Recruiting
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Charles W. Drescher
Recruiting
Mercy Cancer Center �� Carmichael
Carmichael, California, United States
Shahzad Siddique
Recruiting
Mercy San Juan Medical Center
Carmichael, California, United States
Shahzad Siddique
Recruiting
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Wesley Yip
Recruiting
Mercy Cancer Center - Elk Grove
Elk Grove, California, United States
Shahzad Siddique
Recruiting
City of Hope at Irvine Lennar
Irvine, California, United States
Wesley Yip
Recruiting
Providence Queen of the Valley
Napa, California, United States
Charles W. Drescher
Recruiting
Mercy Cancer Center - Rocklin
Rocklin, California, United States
Shahzad Siddique
Recruiting
Mercy Cancer Center - Sacramento
Sacramento, California, United States
Shahzad Siddique
Recruiting
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, United States
Shahzad Siddique
Recruiting
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, United States
Shahzad Siddique
Recruiting
Providence Medical Foundation - Santa Rosa
Santa Rosa, California, United States
Charles W. Drescher
Recruiting
Providence Santa Rosa Memorial Hospital
Santa Rosa, California, United States
Charles W. Drescher
Recruiting
Woodland Memorial Hospital
Woodland, California, United States
Shahzad Siddique
Recruiting
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, United States
Shahzad Siddique
Recruiting
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, United States
Shahzad Siddique
Recruiting
Saint Francis Cancer Center
Colorado Springs, Colorado, United States
Shahzad Siddique
Recruiting
Porter Adventist Hospital
Denver, Colorado, United States
Shahzad Siddique
Recruiting
Mercy Medical Center
Durango, Colorado, United States
Shahzad Siddique
Recruiting
Southwest Oncology Pc
Durango, Colorado, United States
Shahzad Siddique
Recruiting
Saint Anthony Hospital
Lakewood, Colorado, United States
Shahzad Siddique
Recruiting
Littleton Adventist Hospital
Littleton, Colorado, United States
Shahzad Siddique
Recruiting
Longmont United Hospital
Longmont, Colorado, United States
Shahzad Siddique
Recruiting
Parker Adventist Hospital
Parker, Colorado, United States
Shahzad Siddique
Recruiting
Saint Mary Corwin Medical Center
Pueblo, Colorado, United States
Shahzad Siddique
Recruiting
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut, United States
Joseph W. Kim
Recruiting
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut, United States
Joseph W. Kim
Recruiting
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut, United States
Joseph W. Kim
Recruiting
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut, United States
Joseph W. Kim
Recruiting
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, United States
Joseph W. Kim
Recruiting

93 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Mar 2024
Primary completion: 31 Jul 2027
Completion: 30 Jun 2031
Last update posted: 29 Jan 2026
Registered enrollment: 44
Registry id: NCT05806515

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.