Clinical trialNCT05813288TerminatedPhase 3Interventional

A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma (EXHALE-3)

SponsorAreteia TherapeuticsEnrollment654AsthmaAsthma; EosinophilicEosinophilic Asthma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The objective of this clinical study is to investigate the safety, tolerability, and efficacy of dexpramipexole in participants with inadequately controlled severe eosinophilic asthma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Michael E. Wechsler, MD
National Jewish Health
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

282 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Research Site -30054-043
Buenos Aires, Argentina
Research Site 30054-008
Buenos Aires, Argentina
Research Site 30054-012
Buenos Aires, Argentina
Research Site 30054-015
Buenos Aires, Argentina
Research Site 30054-021
Buenos Aires, Argentina
Research Site 30054-024
Buenos Aires, Argentina
Research Site 30054-026
Buenos Aires, Argentina
Research Site 30054-031
Buenos Aires, Argentina
Research Site 30054-034
Buenos Aires, Argentina
Research Site 30054-035
Buenos Aires, Argentina
Research Site 30054-044
Buenos Aires, Argentina
Research Site 30054-045
Buenos Aires, Argentina
Research Site 30054-048
Buenos Aires, Argentina
Research Site 30054-049
Buenos Aires, Argentina
Research Site 30054-050
Buenos Aires, Argentina
Research Site 30054-054
Concepción del Uruguay, Argentina
Research Site 30054-051
Córdoba, Argentina
Research Site 30054-052
Córdoba, Argentina
Research Site 30054-010
Mendoza, Argentina
Research Site 30054-028
Mendoza, Argentina
Research Site 30054-032
Mendoza, Argentina
Research Site 30054-047
Mendoza, Argentina
Research Site 30054-042
Santa Fe, Argentina

Austria

Research Site 30043-013
Salzburg, Austria
Research Site 30043-012
Vienna, Austria
Research Site 30043-001
Weiz, Austria

Brazil

Research Site 30055-036
Curitiba, Brazil
Research Site 30055-021
Porto Alegre, Brazil
Research Site 30055-035
Rio de Janeiro, Brazil
Research Site 30055-025
Salvador, Brazil
Research Site 30055-025
São Paulo, Brazil

Chile

Research Site 30056-013
Santiago, Providencia, Chile
Research Site 30056-009
Curicó, Chile
Research Site 30056-006
Santiago, Chile
Research Site 30056-007
Santiago, Chile
Research Site 30056-010
Santiago, Chile
Research Site 30056-011
Santiago, Chile
Research Site 30056-012
Santiago, Chile
Research Site 30056-013
Santiago, Chile
Research Site 30056-005
Temuco, Chile

242 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Dexpramipexole DihydrochloridePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 27 Mar 2023
Primary completion: 8 Dec 2025
Completion: 8 Dec 2025
Last update posted: 15 Dec 2025
Registered enrollment: 654
Registry id: NCT05813288

Cross-registrations

EU-CTR / CTIS (EudraCT)2023-503693-20

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.