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Clinical trialNCT05843253RecruitingPhase 2Interventional

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

SponsorNationwide Children's HospitalEnrollment120Anaplastic AstrocytomaDiffuse Hemispheric Glioma, H3 G34-MutantDiffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-MutantGlioblastomaGlioblastoma Multiforme+4 more conditions
View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

20 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Sydney Children'S Hospital

    Randwick, New South Wales, Australia

    Recruiting
  • Queensland Children'S Hospital

    South Brisbane, Queensland, Australia

    Recruiting
  • Royal Children'S Hospital

    Melbourne, Victoria, Australia

    Recruiting
  • Perth Children'S Hospital

    Perth, Western Australia, Australia

    Recruiting
Canada
  • the Hospital for Sick Children (sickkids)

    Toronto, Ontario, Canada

    Not, yet, recruiting
  • Montreal Children'S Hospital

    Montreal, Quebec, Canada

    Not, yet, recruiting
Germany
  • Hopp Children'S Cancer Center at Nct Heidelberg (kitz)

    Heidelberg, Baden-Wurttemberg, Germany

    Not, yet, recruiting
New Zealand
  • Starship Children'S Hospital

    Auckland, Grafton, New Zealand

    Not, yet, recruiting
United Kingdom
  • Great Ormond Street Hospital

    London, United Kingdom

    Not, yet, recruiting
United States
  • Children'S Hospital Colorado

    Aurora, Colorado, United States

    Not, yet, recruiting
  • Children'S National Medical Center

    Washington D.C., District of Columbia, United States

    Recruiting
  • Ann & Robert H. Lurie Children'S Hospital of Chicago

    Chicago, Illinois, United States

    Recruiting
  • Dana-Farber Cancer Institute

    Boston, Massachusetts, United States

    Not, yet, recruiting
  • C.S. Mott Children'S Hospital

    Ann Arbor, Michigan, United States

    Recruiting
  • Duke University Health System

    Durham, North Carolina, United States

    Recruiting
  • Cincinnati Children'S Hospital Medical Center

    Cincinnati, Ohio, United States

    Recruiting
  • Nationwide Children'S Hospital

    Columbus, Ohio, United States

    Recruiting
  • Children'S Hospital of Philadelphia

    Philadelphia, Pennsylvania, United States

    Not, yet, recruiting
  • Texas Children'S Hospital

    Houston, Texas, United States

    Recruiting
  • Seattle Children'S Hospital

    Seattle, Washington, United States

    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
22 Aug 2024
Primary completion
31 Aug 2029
Completion
28 Aug 2034
Last update posted
29 May 2026
Registered enrollment
120
Registry id
NCT05843253

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.