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Clinical trialNCT05845398CompletedPhase 1Interventional

Phase 1b Study of DCR-AUD in Healthy Volunteers

SponsorDicerna Pharmaceuticals, Inc., a Novo Nordisk companyEnrollment16Alcohol Use Disorder
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this clinical trial is to test the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of of repeat doses of DCR-AUD in adult healthy volunteers who are social drinkers. The main questions it aims to answer are: * Are repeat doses of DCR-AUD safe and well-tolerated in healthy adults who are social drinkers? * How does the drug behave inside the human body and how it is removed from the human body? * What are the symptoms the drug may cause with alcohol consumption? Participants will: * Receive multiple doses of DCR-AUD. * Have assessment visits through Week 24. * Participate in up to 10 Ethanol Interaction Assessments (EIAs) to see how the body is affected by DCR-AUD. Researchers will compare the groups of participates who receive study drug with the group of participants who receive placebo to see if the study drug is safe and tolerable and whether the study drug has any real effect.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Parexel Los Angeles Early Phase Clinical Unit

    Glendale, California, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

DCR-AUDPlacebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
29 Jan 2023
Primary completion
22 Aug 2023
Completion
22 Aug 2023
Last update posted
14 Jan 2026
Registered enrollment
16
Registry id
NCT05845398

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.