Clinical trialNCT05863195RecruitingPhase 3Interventional

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

SponsorECOG-ACRIN Cancer Research GroupEnrollment408Metastatic Colorectal CarcinomaMetastatic Malignant Neoplasm in the LiverStage IV Colorectal Cancer AJCC v8Unresectable Colorectal Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares hepatic arterial infusion (HAI) (pump chemotherapy) in addition to standard of care chemotherapy versus standard of care chemotherapy alone in treating patients with colorectal cancer that has spread to the liver (liver metastases) and cannot be removed by surgery (unresectable). HAI uses a catheter to carry a tumor-killing chemotherapy drug called floxuridine directly into the liver. HAI is already approved by the Food and Drug Administration (FDA) for use in metastatic colorectal cancer to the liver, but it is only available at a small number of hospitals, and most of the time it is not used until standard chemotherapy stops working. Standard chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Adding HAI to standard chemotherapy may be effective in shrinking or stabilizing unresectable colorectal liver metastases.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Michael Lidsky
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

62 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Withdrawn
Banner Md Anderson Cancer Center
Gilbert, Arizona, United States
Rajesh Ramanathan
Recruiting
Banner-University Medical Center Phoenix
Phoenix, Arizona, United States
Rajesh Ramanathan
Recruiting
Banner Boswell Medical Center
Sun City, Arizona, United States
Rajesh Ramanathan
Recruiting
Uchealth University of Colorado Hospital
Aurora, Colorado, United States
Alexis D. Leal
Recruiting
Um Sylvester Comprehensive Cancer Center at Aventura
Aventura, Florida, United States
Jashodeep Datta
Recruiting
Um Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States
Jashodeep Datta
Recruiting
Um Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States
Jashodeep Datta
Recruiting
Um Sylvester Comprehensive Cancer Center at Hollywood
Hollywood, Florida, United States
Jashodeep Datta
Recruiting
Um Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, United States
Jashodeep Datta
Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Jashodeep Datta
Recruiting
Um Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States
Jashodeep Datta
Recruiting
Emory Saint Joseph'S Hospital
Atlanta, Georgia, United States
Olumide B. Gbolahan
Recruiting
Emory University Hospital/winship Cancer Institute
Atlanta, Georgia, United States
Olumide B. Gbolahan
Recruiting
Northwestern Medicine Cancer Center Old Irving Park
Chicago, Illinois, United States
Shishir K. Maithel
Recruiting
Northwestern University
Chicago, Illinois, United States
Shishir K. Maithel
Recruiting
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Ryan Merkow
Recruiting
Memorial Hospital East
Shiloh, Illinois, United States
Withdrawn
Iu Health North Hospital
Carmel, Indiana, United States
Anita Turk
Recruiting
Indiana University/melvin and Bren Simon Cancer Center
Indianapolis, Indiana, United States
Anita Turk
Recruiting
University of Kentucky/markey Cancer Center
Lexington, Kentucky, United States
Michael J. Cavnar
Recruiting
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States
Benjamin D. Ferguson
Recruiting
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, United States
Kathleen Y. Butler
Recruiting
University of Minnesota/masonic Cancer Center
Minneapolis, Minnesota, United States
Ajay Prakash
Recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Cornelius A. Thiels
Recruiting
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States
Withdrawn
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States
Withdrawn
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, United States
Withdrawn
Siteman Cancer Center-South County
St Louis, Missouri, United States
Withdrawn
Washington University School of Medicine
St Louis, Missouri, United States
Withdrawn
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States
Andrea Cercek →
Recruiting
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States
Andrea Cercek →
Recruiting
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States
Andrea Cercek →
Recruiting
Roswell Park Cancer Institute
Buffalo, New York, United States
Anuradha Krishnamurthy
Recruiting
Memorial Sloan Kettering Commack
Commack, New York, United States
Andrea Cercek →
Recruiting
Memorial Sloan Kettering Westchester
Harrison, New York, United States
Andrea Cercek →
Recruiting
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Andrea Cercek →
Recruiting
Mount Sinai Hospital
New York, New York, United States
James O. Park
Recruiting
Memorial Sloan Kettering Nassau
Uniondale, New York, United States
Andrea Cercek →
Recruiting
Duke University Medical Center
Durham, North Carolina, United States
Hope E. Uronis
Recruiting

22 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bevacizumab →Cetuximab →FloxuridineFluorouracil →Irinotecan →Leucovorin →Oxaliplatin →Panitumumab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 19 Oct 2023
Primary completion: 30 Jun 2029
Completion: 30 Jun 2034
Last update posted: 18 Aug 2026
Registered enrollment: 408
Registry id: NCT05863195

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.