Clinical trialNCT05863351Active, not recruitingPhase 3Interventional

Focused Radiation Versus Systemic Therapy for Kidney Cancer Patients With Limited Metastasis, SOAR Study

SponsorECOG-ACRIN Cancer Research GroupEnrollment472Metastatic Renal Cell CarcinomaStage IV Renal Cell Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares the effect of stero-ablative radiotherapy (SAbR) followed by standard of care systemic therapy, to standard of care systemic therapy alone, in patients with kidney cancer that has spread from where it first started (primary site) to a limited (2-5) number of places in the body (metastatic). Study doctors want to find out if this approach is better or worse than the usual approach for metastatic kidney cancer. The usual approach is defined as the care most people get for metastatic kidney cancer which includes systemic therapy such as immunotherapy (given through the veins) and/or small molecular inhibitor (tablets taken by mouth). Radiotherapy uses high energy x-rays to kill cancer cells and shrink tumors. SAbR uses special equipment to position a patient and deliver radiation to tumors with high precision. Giving SAbR prior to systemic therapy may kill more tumor cells than the usual approach, which is systemic therapy alone.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Raquibul Hannan
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

108 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Mayo Clinic Hospital in Arizona
Phoenix, Arizona, United States
Uchealth University of Colorado Hospital
Aurora, Colorado, United States
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado, United States
Poudre Valley Hospital
Fort Collins, Colorado, United States
Uchealth Greeley Hospital
Greeley, Colorado, United States
Uchealth Highlands Ranch Hospital
Highlands Ranch, Colorado, United States
Medical Center of the Rockies
Loveland, Colorado, United States
Sibley Memorial Hospital
Washington D.C., District of Columbia, United States
Mayo Clinic in Florida
Jacksonville, Florida, United States
Illinois Cancercare-Bloomington
Bloomington, Illinois, United States
Osf Saint Joseph Medical Center
Bloomington, Illinois, United States
Illinois Cancercare-Canton
Canton, Illinois, United States
Illinois Cancercare-Carthage
Carthage, Illinois, United States
Centralia Oncology Clinic
Centralia, Illinois, United States
Northwestern University
Chicago, Illinois, United States
University of Illinois
Chicago, Illinois, United States
Carle at the Riverfront
Danville, Illinois, United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States
Decatur Memorial Hospital
Decatur, Illinois, United States
Carle Physician Group-Effingham
Effingham, Illinois, United States
Crossroads Cancer Center
Effingham, Illinois, United States
Illinois Cancercare-Eureka
Eureka, Illinois, United States
Illinois Cancercare-Galesburg
Galesburg, Illinois, United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States
Illinois Cancercare-Kewanee Clinic
Kewanee, Illinois, United States
Illinois Cancercare-Macomb
Macomb, Illinois, United States
Carle Physician Group-Mattoon/charleston
Mattoon, Illinois, United States
Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States
Hshs Saint Elizabeth'S Hospital
O'Fallon, Illinois, United States
Illinois Cancercare-Ottawa Clinic
Ottawa, Illinois, United States
Illinois Cancercare-Pekin
Pekin, Illinois, United States
Illinois Cancercare-Peoria
Peoria, Illinois, United States
Osf Saint Francis Medical Center
Peoria, Illinois, United States
Osf Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, Illinois, United States
Illinois Cancercare-Peru
Peru, Illinois, United States
Illinois Cancercare-Princeton
Princeton, Illinois, United States
Memorial Medical Center
Springfield, Illinois, United States
Southern Illinois University School of Medicine
Springfield, Illinois, United States

68 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 7 Sept 2023
Primary completion: 1 Dec 2030
Completion: 1 Aug 2037
Last update posted: 17 Jul 2026
Registered enrollment: 472
Registry id: NCT05863351

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.