Clinical trialNCT05907629RecruitingObservational

Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

SponsorYale UniversityEnrollment300Intracranial Atherosclerotic Stenosis (ICAS)Stroke

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Adam de Havenon, MD, MS
Yale University
Principal Investigator
clinicaltrials.gov ↗
David Liebeskind, MD
University of California, Los Angeles
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Rano Chatterjee, MD
Washington University School of Medicine
Principal Investigator
clinicaltrials.gov ↗
Sepideh Amin-Hanjani, MD
University Hospitals
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

28 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama Hospital
Birmingham, Alabama, United States
Ekaterina Bakradze
Recruiting
University of Colorado Hospital
Aurora, Colorado, United States
Not, yet, recruiting
Hartford Hospital
Hartford, Connecticut, United States
Not, yet, recruiting
Yale New Haven Hospital
New Haven, Connecticut, United States
James Giles
Recruiting
Medstar Washington Hospital Center
Washington D.C., District of Columbia, United States
Sana Somani
Recruiting
Baptist Medical Center Jacksonville
Jacksonville, Florida, United States
Ricardo Hanel
Recruiting
Jackson Memorial Hospital, Miami
Miami, Florida, United States
Victor Del Brutto
Recruiting
Cleveland Clinic Tradition Hospital
Port Saint Lucie, Florida, United States
Not, yet, recruiting
Sih Memorial Hospital of Carbondale
Carbondale, Illinois, United States
Andrea Loggini
Not, yet, recruiting
University of Chicago Medical Center
Chicago, Illinois, United States
Tareq Kass-Hout
Recruiting
University of Illinois Hospital
Chicago, Illinois, United States
Ali Alaraj, MD
Recruiting
Metro Health Hospital
Wyoming, Michigan, United States
Not, yet, recruiting
M Health Fairview University of Minnesota Medical Center
Minneapolis, Minnesota, United States
Not, yet, recruiting
Barnes Jewish Hospital
St Louis, Missouri, United States
Yan Wang, MD
Recruiting
Buffalo General Medical Center
Buffalo, New York, United States
Amit Kandel
Recruiting
North Shore University Hospita
Manhasset, New York, United States
Rohan Arora
Recruiting
Nyp Columbia University Medical Center
New York, New York, United States
Not, yet, recruiting
Carolinas Medical Center
Charlotte, North Carolina, United States
Rahul Karamchandani
Not, yet, recruiting
Duke University Hospital
Durham, North Carolina, United States
Not, yet, recruiting
Cleveland Clinic Akron General
Akron, Ohio, United States
Not, yet, recruiting
University of Cincinnati Medical Center
Cincinnati, Ohio, United States
Yasmin AZIZ
Recruiting
Uh Cleveland Medical Center
Cleveland, Ohio, United States
Sepideh Amin-Hanjani
Recruiting
Mercy St. Vincent Medical Center
Toledo, Ohio, United States
Not, yet, recruiting
Prisma Health Richland Hospital
Columbia, South Carolina, United States
Not, yet, recruiting
University of Texas Medical Branch
Galveston, Texas, United States
Recruiting
Memorial Hermann Texas Medical Center
Houston, Texas, United States
Not, yet, recruiting
Covenant Medical Center
Lubbock, Texas, United States
Not, yet, recruiting
Uva Medical Center
Charlottesville, Virginia, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 24 Jun 2024
Primary completion: 31 Mar 2029
Completion: 31 Mar 2029
Last update posted: 16 Jul 2026
Registered enrollment: 300
Registry id: NCT05907629

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.