Clinical trialNCT05931276RecruitingPhase 3Interventional

CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes

SponsorVA Office of Research and DevelopmentEnrollment2,540End-Stage Kidney DiseaseEnd-Stage Renal Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Areef Ishani, MD MS
Minneapolis VA Health Care System, Minneapolis, MN
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Va Long Beach Healthcare System, Long Beach, Ca
Long Beach, California, United States
Recruiting
North Florida/south Georgia Veterans Health System, Gainesville, Fl
Gainesville, Florida, United States
Recruiting
Atlanta Va Medical and Rehab Center, Decatur, Ga
Decatur, Georgia, United States
Recruiting
Iowa City Va Health Care System, Iowa City, Ia
Iowa City, Iowa, United States
Recruiting
Va Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, Ma
Boston, Massachusetts, United States
Not, yet, recruiting
Minneapolis Va Health Care System, Minneapolis, Mn
Minneapolis, Minnesota, United States
Areef Ishani, MD MS
Recruiting
Omaha Va Nebraska-Western Iowa Health Care System, Omaha, Ne
Omaha, Nebraska, United States
Recruiting
New Mexico Va Health Care System, Albuquerque, Nm
Albuquerque, New Mexico, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carvedilol →Metoprolol →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 May 2024
Primary completion: 31 Dec 2026
Completion: 31 Dec 2028
Last update posted: 9 Jan 2026
Registered enrollment: 2,540
Registry id: NCT05931276

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.