Clinical trialNCT05932589RecruitingObservational

Neurophysiologic Biomarkers in Rett Syndrome

SponsorChildren's Hospital of PhiladelphiaEnrollment202RTTRett SyndromeRett Syndrome, Atypical

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: * Do these biomarkers change during clinical changes in individuals with RTT? * Are biomarkers stable over time in clinically stable individuals? * Do these biomarkers correlate with severity of RTT? Participants will be asked to undergo an electroencephalogram (EEG) with measurements of Evoked Potentials (EP) to measure electrical activity in the brain. Researchers will compare findings in individuals with RTT to those in typically developing individuals to see if there are differences between the two groups.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Eric Marsh, MD, PhD
Children's Hospital of Philadelphia
Principal Investigator
clinicaltrials.gov ↗
Jeffrey Neul, MD, PhD
Vanderbilt University Medical Cener
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Children'S Hospital of Los Angeles
Los Angeles, California, United States
Payal Kenia Gu, MDShefali Spurling Jeste, MD
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Timothy Benke, MD, PhD
Recruiting
Boston Children'S Hospital
Brookline, Massachusetts, United States
April Levin, MDDavid Lieberman, MD, PhD
Recruiting
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Eric Marsh, MD, PhD
Recruiting
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Jeffrey Neul, MD, PhD
Recruiting
Texas Children'S Hospital
Houston, Texas, United States
Bernhard Suter, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 11 Oct 2023
Primary completion: 31 Mar 2028
Completion: 31 Mar 2029
Last update posted: 20 Oct 2025
Registered enrollment: 202
Registry id: NCT05932589

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.