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Clinical trialNCT05959707SuspendedPhase 1Interventional

Evaluating the Safety, Tolerability, and Pharmacokinetics of Monoclonal Antibodies in Healthy Participants

SponsorHIV Vaccine Trials NetworkEnrollment77HIV Infections
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Part A: The purpose of this part is to study how the body's immune system reacts to a lab-made HIV-1 monoclonal antibody against HIV antigen when given in different doses. The study will also evaluate if the antibody is safe to give to people and does not make them too uncomfortable. Part B: The purpose of this part is to study how the body's immune system reacts to a combination of lab-made HIV-1 monoclonal antibodies against HIV antigens when given in different doses. The study also wants to see if the way the antibodies are given affects the immune response.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

South Africa
  • Groote Schuur Hiv Crs

    Cape Town, Western Cape, South Africa

  • Emavundleni Crs

    Klipfontein, Western Cape, South Africa

  • Caprisa Ethekwini Crs

    Durban, South Africa

  • Soweto Hptn Crs

    Johannesburg, South Africa

  • Ward 21 Crs

    Johannesburg, South Africa

  • Klerksdorp Crs

    Klerksdorp, South Africa

  • Isipingo Crs

    KwaZulu, South Africa

  • Soshanguve

    Soshanguve, South Africa

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PGDM1400LSPGT121.414.LSVRC01.23LS
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
14 Aug 2024
Primary completion
14 Jan 2025
Completion
14 Jan 2025
Last update posted
5 Jul 2024
Registered enrollment
77
Registry id
NCT05959707
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.