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Clinical trialNCT05961839TerminatedPhase 1Interventional

Study of SGR-2921 in Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

SponsorSchrödinger, Inc.Enrollment66Acute Myeloid LeukemiaHigh-Risk and Very High-Risk Myelodysplastic Syndromes
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) and/or recommended dose (RD) of SGR-2921.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Colorado Blood Cancer Institute

    Denver, Colorado, United States

  • the University of Kansas Clinical Research Center

    Fairway, Kansas, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, United States

  • the Ohio State University Wexner Medical Center - James Cancer Hospital

    Columbus, Ohio, United States

  • Oncology Associates of Oregon, P.C.

    Eugene, Oregon, United States

  • Oregon Health & Science University - Knight Cancer Institute - Center of Hematologic Malignancies

    Portland, Oregon, United States

  • Thomas Jefferson University, Sidney Kimmel Cancer Center, Clinical Research Organization

    Philadelphia, Pennsylvania, United States

  • Tristar Bone Marrow Transplant, Llc

    Nashville, Tennessee, United States

  • St. David'S South Austin Medical Center

    Austin, Texas, United States

  • Md Anderson Cancer Center

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

SGR-2921
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
27 Sept 2023
Primary completion
14 Aug 2025
Completion
9 Sept 2025
Last update posted
22 Sept 2025
Registered enrollment
66
Registry id
NCT05961839

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.