Clinical trialNCT05991453RecruitingInterventional

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

SponsorWashington University School of MedicineEnrollment13,000AnesthesiaAnesthesia AwarenessAnesthesia ComplicationAnesthesia MorbidityPain, PostoperativeQuality of Life+2 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Allison Janda, MD
University of Michigan
Study Director
clinicaltrials.gov ↗
Bethany Pennington, PharmD
Washington University School of Medicine
Study Director
clinicaltrials.gov ↗
Douglas Colquhoun, MBChB
University of Michigan
Study Director
clinicaltrials.gov ↗
Mark Neuman, MD
University of Pennsylvania
Study Director
clinicaltrials.gov ↗
Michael S Avidan, MBBCh
Washington University School of Medicine
Principal Investigator
clinicaltrials.gov ↗
Sachin Kheterpal, MD
University of Michigan
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

24 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Arkansas for Medical Sciences (uams)
Little Rock, Arkansas, United States
Geoffrey Muller, MD
Recruiting
University of California San Francisco
San Francisco, California, United States
Jennifer Woodbury, MDJeremy Juang, MDLee-lynn Chen, MDMatthieu Legrand, MD
Recruiting
Stanford University
Stanford, California, United States
David Drover, MD
Not, yet, recruiting
Yale School of Medicine
New Haven, Connecticut, United States
Jaime B Hyman, MDRobert B Schonberger, MD
Recruiting
Johns Hopkins School of Medicine
Baltimore, Maryland, United States
Joseph Walpole, MD, PhD
Recruiting
Brigham & Women'S
Boston, Massachusetts, United States
Luigino Nascimben, MD
Recruiting
Massachusetts General Hospital
Boston, Massachusetts, United States
Amit Bardia, MD
Recruiting
University of Michigan
Ann Arbor, Michigan, United States
Allison Janda, MDSachin Kheterpal, MDSathish Kumar, MD
Recruiting
Henry Ford Health
Detroit, Michigan, United States
Anoop Chhina, MD
Recruiting
Washington University School of Medicine
St Louis, Missouri, United States
Michael S Avidan, MBBchStephen Gregory, MD
Recruiting
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States
Stacie Deiner, MD
Recruiting
Nyu Langone
New York, New York, United States
Simon Tom, MD
Recruiting
Weill Cornell Medicine
New York, New York, United States
Kane O Pryor, MD
Recruiting
University of North Carolina School of Medicine
Chapel Hill, North Carolina, United States
Jay W Schoenherr, MD
Recruiting
Duke University
Durham, North Carolina, United States
Michael Manning, MD
Recruiting
Wake Forest
Winston-Salem, North Carolina, United States
Ashish Khanna, MD
Recruiting
Oregon Health and Sciences University
Portland, Oregon, United States
Michael Aziz, MD
Recruiting
Temple University
Philadelphia, Pennsylvania, United States
Sean Baskin, DO
Recruiting
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Caoimhe Duffy, MD
Not, yet, recruiting
University of Texas Southwestern
Dallas, Texas, United States
Kunal Karamchandani, MD
Recruiting
University of Texas - Md Anderson
Houston, Texas, United States
Juan Cata, MD
Recruiting
University of Utah - Medical
Salt Lake City, Utah, United States
Rachel Danowit, MD
Recruiting
Uva Health
Charlottesville, Virginia, United States
Bhiken Naik, MD
Recruiting
University of Washington
Seattle, Washington, United States
Karen Domino, MDWil Van Cleve, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 13 Sept 2023
Primary completion: 31 Jul 2027
Completion: 31 Jul 2028
Last update posted: 4 Sept 2026
Registered enrollment: 13,000
Registry id: NCT05991453

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.