Clinical trialNCT06042855CompletedPhase 3Interventional

ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)

SponsorSusanna Naggie, MDEnrollment3,214Covid19

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to evaluate the effectiveness of repurposed medications (study drug(s) in reducing symptoms of non-hospitalized participants with mild to moderate COVID-19. Participants will receive either study drug or placebo. Participants will self-report any new or worsening symptoms or medical events experienced while taking study drug or placebo. This study is intended to be all remote with no in person visits, unless the study team feels it is in the best interest of a participant to be seen in person. Prior and current drug arms are listed on clinicaltrials.gov and will be updated with the activation of any new drug arms. Each study arm will also have its own clinicaltrials.gov entry and will include "Pro00107921" in the Unique Protocol ID.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Adrian Hernandez, MD
Duke Clinical Research Institute
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Susanna Naggie, MD
Duke Clinical Research Institute
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

110 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Chandler Regional Medical Center
Chandler, Arizona, United States
Lamb Health, Llc
Gilbert, Arizona, United States
First Care Medical Clinic
Mesa, Arizona, United States
Trident Health Center
Peoria, Arizona, United States
University of Arkansas Medical Sciences
Little Rock, Arkansas, United States
Hoag Memorial Hospital Presbyterian
Newport Beach, California, United States
Assuta Family Medical Group Apmc
North Hollywood, California, United States
Stanford
Palo Alto, California, United States
Olive View - Ucla Medical Center
Sylmar, California, United States
Doctors Medical Group of Colorado Springs, P.C.
Colorado Springs, Colorado, United States
Pine Ridge Family Medicine Inc.
Colorado Springs, Colorado, United States
Tabitha B. Fortt, M.D., Llc
Stamford, Connecticut, United States
George Washington University Hospital
Washington D.C., District of Columbia, United States
Arena Medical Group
Deerfield Beach, Florida, United States
Lupus Foundation of Gainesville
Gainesville, Florida, United States
University of Florida Health
Gainesville, Florida, United States
L and A Morales Healthcare, Inc
Hialeah, Florida, United States
Amron Vitality and Wellness Center, Llc
Jacksonville, Florida, United States
University of Florida-Jax-Ascent
Jacksonville, Florida, United States
Sunshine Walk in Clinic
Lake Mary, Florida, United States
Lakeland Regional Medical Center
Lakeland, Florida, United States
Jackson Memorial Hospital
Miami, Florida, United States
University of Miami
Miami, Florida, United States
Well Pharma Medical Research
Miami, Florida, United States
the Angel Medical Research Corporation
Miami Lakes, Florida, United States
Innovation Clinical Trials Inc.
Palmetto Bay, Florida, United States
Lice Source Services Plantation
Plantation, Florida, United States
Premier Health
St. Petersburg, Florida, United States
Tallahassee Memorial Hospital
Tallahassee, Florida, United States
Tampa General Hospital
Tampa, Florida, United States
Uf Health Precision Health Research
The Villages, Florida, United States
Emory Healthcare
Atlanta, Georgia, United States
Morehouse School of Medicine
Atlanta, Georgia, United States
Essential Medical Care, Inc.
College Park, Georgia, United States
Clincept, Llc
Columbus, Georgia, United States
Hope Clinical Research and Wellness
Conyers, Georgia, United States
David Kavtaradze Md, Inc.
Cordele, Georgia, United States
Elite Family Practice
Douglasville, Georgia, United States
Christ the King Health Care, P.C.
Loganville, Georgia, United States
Miller Family Practice, Llc
Macon, Georgia, United States

70 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Metformin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 5 Sept 2023
Primary completion: 3 Jun 2024
Completion: 4 Nov 2024
Last update posted: 18 Nov 2025
Registered enrollment: 3,214
Registry id: NCT06042855

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.