Clinical trialNCT06043440RecruitingPhase 2Interventional

Down Syndrome Obstructive Sleep Apnea

SponsorBrigham and Women's HospitalEnrollment230Down SyndromeObstructive Sleep Apnea

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) with moderate to severe Obstructive Sleep Apnea (OSA).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Raouf Amin
Children's Hospital Medical Center, Cincinnati
Principal Investigator
clinicaltrials.gov ↗
Susan Redline
Brigham and Women's Hospital
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Children'S Hospital of Los Angeles
Los Angeles, California, United States
Sally Ward, MD
Recruiting
University of Michigan, Ann Arbor Hospital
Ann Arbor, Michigan, United States
Ronald Chervin, MD
Recruiting
Cincinnati Children'S Hospital Medical Center
Cincinnati, Ohio, United States
Raouf Amin, MD
Recruiting
Rainbow Babies and Children'S Hospital, Case Medical Center
Cleveland, Ohio, United States
Sally Ibrahim, MD
Recruiting
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Christopher Cielo, MD
Recruiting
East Virginia Medical Center
Norfolk, Virginia, United States
Cristina Baldassari, MD
Recruiting
Seattle Children'S Hospital
Seattle, Washington, United States
Maida Chen, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Oxygen

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 24 Oct 2023
Primary completion: 30 Nov 2027
Completion: 30 Dec 2027
Last update posted: 20 Apr 2025
Registered enrollment: 230
Registry id: NCT06043440

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.