Clinical trialNCT06064097RecruitingPhase 2Interventional

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

SponsorNational Cancer Institute (NCI)Enrollment50Stage II Nasopharyngeal Carcinoma AJCC v8Stage III Nasopharyngeal Carcinoma AJCC v8Stage IV Nasopharyngeal Carcinoma AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial tests effects of nivolumab in combination with chemotherapy drugs prior to radiation therapy patients with nasopharyngeal carcinoma (NPC). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Researchers want to find out what effects, good and/or bad, adding nivolumab to chemotherapy has on patients with newly diagnosed NPC. In addition, they want to find out if children with NPC may be treated with less radiation therapy and whether this decreases the side effects of therapy.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Robyn D Gartrell
Children's Oncology Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

86 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

John Hunter Children'S Hospital
Hunter Regional Mail Centre, New South Wales, Australia
Kristy McCarthy
Recruiting

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Victor A. Lewis
Recruiting
University of Alberta Hospital
Edmonton, Alberta, Canada
Sarah J. McKillop
Recruiting
Hospital for Sick Children
Toronto, Ontario, Canada
Avram E. Denburg
Recruiting
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada
Monia Marzouki
Recruiting
the Montreal Children'S Hospital of the Muhc
Montreal, Quebec, Canada
Stephanie Mourad
Recruiting
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada
Josee Brossard
Recruiting

New Zealand

Starship Children'S Hospital
Grafton, Auckland, New Zealand
Leander D. Timothy
Recruiting
Christchurch Hospital
Christchurch, New Zealand
Tristan Pettit
Recruiting

Puerto Rico

University Pediatric Hospital
San Juan, Puerto Rico
Maria E. Echevarria
Recruiting

United States

Children'S Hospital of Alabama
Birmingham, Alabama, United States
Jamie M. Aye
Recruiting
Phoenix Childrens Hospital
Phoenix, Arizona, United States
Alok K. Kothari
Recruiting
Arkansas Children'S Hospital
Little Rock, Arkansas, United States
Michael W. Bishop
Recruiting
Kaiser Permanente Downey Medical Center
Downey, California, United States
Robert M. Cooper
Recruiting
Loma Linda University Medical Center
Loma Linda, California, United States
Albert Kheradpour
Recruiting
Children'S Hospital Los Angeles
Los Angeles, California, United States
Rachana Shah
Recruiting
Valley Children'S Hospital
Madera, California, United States
Ruetima Titapiwatanakun
Recruiting
Kaiser Permanente-Oakland
Oakland, California, United States
Aarati V. Rao
Recruiting
Ucsf Benioff Children'S Hospital Oakland
Oakland, California, United States
Jennifer G. Michlitsch
Recruiting
Rady Children'S Hospital - San Diego
San Diego, California, United States
William D. Roberts
Recruiting
Ucsf Medical Center-Mission Bay
San Francisco, California, United States
Arun A. Rangaswami
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Navin R. Pinto
Recruiting
Connecticut Children'S Medical Center
Hartford, Connecticut, United States
Michael S. Isakoff
Recruiting
Alfred I Dupont Hospital for Children
Wilmington, Delaware, United States
Sridhi Patel
Recruiting
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Jeffrey S. Dome
Recruiting
Uf Health Cancer Institute - Gainesville
Gainesville, Florida, United States
Brian Stover
Recruiting
Nemours Children'S Clinic-Jacksonville
Jacksonville, Florida, United States
Sridhi Patel
Recruiting
Nicklaus Children'S Hospital
Miami, Florida, United States
Maggie E. Fader
Recruiting
Arnold Palmer Hospital for Children
Orlando, Florida, United States
Zhongbo Hu
Recruiting
Nemours Children'S Hospital
Orlando, Florida, United States
Sridhi Patel
Recruiting
Nemours Children'S Clinic - Pensacola
Pensacola, Florida, United States
Jeffrey H. Schwartz
Recruiting
Saint Joseph'S Hospital/children'S Hospital-Tampa
Tampa, Florida, United States
Don E. Eslin
Recruiting
Children'S Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, United States
Suspended
Lurie Children'S Hospital-Chicago
Chicago, Illinois, United States
Amy L. Walz
Recruiting
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Lorraine E. Canham
Recruiting
Riley Hospital for Children
Indianapolis, Indiana, United States
Marissa Just
Recruiting
University of Kentucky/markey Cancer Center
Lexington, Kentucky, United States
James T. Badgett
Not, yet, recruiting
Children'S Hospital New Orleans
New Orleans, Louisiana, United States
Maria C. Velez-Yanguas
Recruiting
Maine Children'S Cancer Program
Scarborough, Maine, United States
Aaron R. Weiss
Recruiting
Johns Hopkins University/sidney Kimmel Cancer Center
Baltimore, Maryland, United States
Robyn D. Gartrell
Recruiting

46 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cisplatin →Gemcitabine →Nivolumab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 25 Jun 2024
Primary completion: 31 Mar 2027
Completion: 31 Mar 2027
Last update posted: 20 Aug 2026
Registered enrollment: 50
Registry id: NCT06064097

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.