Clinical trialNCT06070350RecruitingPhase 3Interventional

Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children

SponsorPhilip SpinellaEnrollment1,000Hemorrhagic ShockTrauma Injury

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The MATIC-2 is a multicenter clinical trial enrolling children who are less than 18 years of age with hemorrhagic shock potentially needing significant blood transfusion. The primary objective of the clinical trial is to determine the effectiveness of Low Titer Group O Whole Blood (LTOWB) compared to component therapy (CT), and Tranexamic Acid (TXA) compared to placebo in decreasing 24-hour all-cause mortality in children with traumatic life threatening hemorrhage.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Philip C Spinella, MD
Univesrity of Pittsburgh
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

23 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Arizona
Tucson, Arizona, United States
Louis Magnotti, MD
Recruiting
Arkansas Children'S Hospital
Little Rock, Arkansas, United States
Todd Maxson, MD
Recruiting
University of California Davis
Sacramento, California, United States
Daniel Nishijima, MD
Recruiting
Children'S National Hospital
Washington D.C., District of Columbia, United States
Randall Burd, MD
Recruiting
Emory University-Arthur M. Blank Hospital
Atlanta, Georgia, United States
Ruth Hwu, MD
Recruiting
Emory University-Scottish Rite Hospital
Atlanta, Georgia, United States
Terminated
Tulane School of Medicine
New Orleans, Louisiana, United States
Withdrawn
University of Mississippi Medical Center
Jackson, Mississippi, United States
Matthew Kutcher, MD
Recruiting
Washington University of St. Louis
St Louis, Missouri, United States
Lindsay Clukies, MD
Recruiting
University of New Mexico
Albuquerque, New Mexico, United States
Sarah Moore, MD
Recruiting
Wake Forest University Health Sciences
Wake Forest, North Carolina, United States
Lucas Neff, MD
Recruiting
Nationwide Children'S Hospital
Columbus, Ohio, United States
Julie Leonard, MD
Recruiting
Oregon Health and Science University
Portland, Oregon, United States
Trisha Wong, MD
Recruiting
Children'S Hospital of Pittsburgh of Upmc
Pittsburgh, Pennsylvania, United States
Ward Richardson, MD
Recruiting
Lebonheur Children'S Hospital
Memphis, Tennessee, United States
Regan Williams, MD
Recruiting
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Harold Lovvorn, MD
Not, yet, recruiting
the University of Texas Southwestern Medical Center
Dallas, Texas, United States
Terminated
Baylor College of Medicine
Houston, Texas, United States
Adam Vogel, MD
Recruiting
Children'S Memorial Hermann Hospital
Houston, Texas, United States
Charles Cox, MD
Recruiting
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States
Susannah Nicholson, MD
Recruiting
Primary Children'S Hospital
Salt Lake City, Utah, United States
Katie Russell, MD
Recruiting
University of Washington Harborview
Seattle, Washington, United States
Bryce Robinson, MD
Recruiting
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Katherine Flynn-O'Brien, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Component TherapyLow Titer Group O Whole BloodPlaceboTranexamic acid →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Nov 2024
Primary completion: 1 Jun 2028
Completion: 1 Oct 2028
Last update posted: 17 Sept 2026
Registered enrollment: 1,000
Registry id: NCT06070350

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.