Clinical trialNCT06080698RecruitingInterventional

Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial

SponsorJohns Hopkins UniversityEnrollment1,030Gram-negative Bacteremia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy for the treatment of Gram-Negative BloodStream Infection (GN-BSI) is as effective but safer than remaining on intravenous (IV) antibiotic therapy for the duration of treatment.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Pranita D Tamma, MD, MHS
Children's Hospital of Philadelphia
Principal Investigator
clinicaltrials.gov ↗
Sara E Cosgrove, MD, MS
Johns Hopkins University
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

11 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California, San Francisco
San Francisco, California, United States
Sarah Doernberg, MD
Recruiting
Denver Health Hospital Authority
Denver, Colorado, United States
Tomothy Jerkins, MD
Recruiting
Johns Hopkins University Hospital Systems
Baltimore, Maryland, United States
Michael Melia, MD
Recruiting
University of Maryland Medical Center
Baltimore, Maryland, United States
Anthony Harris, MD
Recruiting
Mayo Clinic
Rochester, Minnesota, United States
Gina Suh, MD
Recruiting
Rutgers-Rwj University Hospital
New Brunswick, New Jersey, United States
Keith Kaye, MD
Recruiting
Duke University
Durham, North Carolina, United States
Joshua Thaden, MD
Recruiting
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Lauren Dutcher, MD
Recruiting
Vanderbilt University Medical Center
Nashville, Tennessee, United States
George Nelson, MD
Recruiting
Houston Methodist
Houston, Texas, United States
William L Musick, PharmD
Recruiting
Carilion Clinic
Roanoke, Virginia, United States
Lana Wahid, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Intravenous AntibioticsOral Antibiotics

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Feb 2024
Primary completion: 31 May 2027
Completion: 30 Jun 2027
Last update posted: 11 Mar 2026
Registered enrollment: 1,030
Registry id: NCT06080698

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.