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Clinical trialNCT06096259RecruitingPhase 2Interventional

Preventing Injured Knees From osteoArthritis: Severity Outcomes

SponsorBrigham and Women's HospitalEnrollment512ACL TearOsteoarthritis, KneePost-traumatic Osteoarthritis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction. This research study will compare metformin to placebo. The placebo tablet looks exactly like metformin, but contains no metformin. Placebos are used in research studies to see if the results are due to the study drug or due to other reasons. Metformin is approved by the U.S. Food and Drug Administration (FDA) to treat type II diabetes. Notably, it also has anti-inflammatory effects, suggesting it could benefit people who have an ACL injury and are undergoing ACL reconstruction.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Emory University

    Atlanta, Georgia, United States

    Gregory D Myer, PhD
    Recruiting
  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, United States

    Brian R Wolf, MDDon D Anderson, PhD
    Recruiting
  • University of Kentucky

    Lexington, Kentucky, United States

    Austin V Stone, MD, PhD
    Recruiting
  • Brigham and Women'S Hospital

    Boston, Massachusetts, United States

    Cale A Jacobs, PhDMorgan H Jones, MD, MPH
    Recruiting
  • University of Nebraska Medical Center

    Omaha, Nebraska, United States

    Elizabeth A Wellsandt, PT, PhDYvonne Golightly, PT, PhD
    Recruiting
  • Hospital for Special Surgery

    New York, New York, United States

    Miguel Otero, PhDScott A Rodeo, MD
    Recruiting
  • the University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, United States

    Brian G Pietrosimone, PhDJoe M Hart, PhD
    Recruiting
  • Cleveland Clinic

    Cleveland, Ohio, United States

    Kurt Spindler, MD
    Recruiting
  • the Ohio State University

    Columbus, Ohio, United States

    Laura C Schmitt, PT, PhDRobert A Magnussen, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Metformin →Placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
6 May 2024
Primary completion
31 Dec 2028
Completion
31 Dec 2029
Last update posted
29 Apr 2025
Registered enrollment
512
Registry id
NCT06096259
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.