Clinical trialNCT06096844RecruitingPhase 3Interventional

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

SponsorNational Cancer Institute (NCI)Enrollment304Advanced Lung Non-Small Cell CarcinomaStage IIIB Lung Cancer AJCC v8Stage IIIC Lung Cancer AJCC v8Stage IV Lung Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab and chemotherapy may help stabilize lung cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Megan A Baumgart
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

328 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Highlands Oncology Group - Fayetteville
Fayetteville, Arkansas, United States
Joseph T. Beck
Recruiting
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States
Jay W. Carlson
Recruiting
Highlands Oncology Group - Rogers
Rogers, Arkansas, United States
Joseph T. Beck
Recruiting
Highlands Oncology Group
Springdale, Arkansas, United States
Joseph T. Beck
Recruiting
Kaiser Permanente Dublin
Dublin, California, United States
Active, not recruiting
Kaiser Permanente-Fremont
Fremont, California, United States
Active, not recruiting
Kaiser Permanente Fresno Orchard Plaza
Fresno, California, United States
Active, not recruiting
Kaiser Permanente-Fresno
Fresno, California, United States
Active, not recruiting
Kaiser Permanente- Modesto Mob Ii
Modesto, California, United States
Active, not recruiting
Kaiser Permanente-Modesto
Modesto, California, United States
Active, not recruiting
Kaiser Permanente-Oakland
Oakland, California, United States
Active, not recruiting
Va Palo Alto Health Care System
Palo Alto, California, United States
Active, not recruiting
Kaiser Permanente-Roseville
Roseville, California, United States
Active, not recruiting
Kaiser Permanente Downtown Commons
Sacramento, California, United States
Active, not recruiting
Kaiser Permanente-South Sacramento
Sacramento, California, United States
Active, not recruiting
Kaiser Permanente-San Francisco
San Francisco, California, United States
Active, not recruiting
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, United States
Active, not recruiting
Kaiser Permanente San Leandro
San Leandro, California, United States
Active, not recruiting
Kaiser San Rafael-Gallinas
San Rafael, California, United States
Active, not recruiting
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States
Active, not recruiting
Kaiser Permanente-Santa Rosa
Santa Rosa, California, United States
Active, not recruiting
Kaiser Permanente-South San Francisco
South San Francisco, California, United States
Active, not recruiting
Kaiser Permanente-Vallejo
Vallejo, California, United States
Active, not recruiting
Kaiser Permanente-Walnut Creek
Walnut Creek, California, United States
Active, not recruiting
Stamford Hospital/bennett Cancer Center
Stamford, Connecticut, United States
Salvatore A. Del Prete
Recruiting
Veterans Affairs Connecticut Healthcare System-West Haven Campus
West Haven, Connecticut, United States
Herta H. Chao
Recruiting
George Washington University Medical Center
Washington D.C., District of Columbia, United States
Prashanth Ashok Kumar
Recruiting
Um Sylvester Comprehensive Cancer Center at Aventura
Aventura, Florida, United States
Chukwuemeka (Emeka) V. Ikpeazu
Recruiting
Um Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States
Chukwuemeka (Emeka) V. Ikpeazu
Recruiting
Um Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States
Chukwuemeka (Emeka) V. Ikpeazu
Recruiting
Holy Cross Hospital
Fort Lauderdale, Florida, United States
Christopher M. Reynolds
Recruiting
Malcom Randall Veterans Administration Medical Center
Gainesville, Florida, United States
Brittany K. Rogers
Recruiting
Uf Health Cancer Institute - Gainesville
Gainesville, Florida, United States
Aline F. Fares
Recruiting
the Watson Clinic
Lakeland, Florida, United States
Leonard J. Gitter
Recruiting
Um Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, United States
Chukwuemeka (Emeka) V. Ikpeazu
Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Chukwuemeka (Emeka) V. Ikpeazu
Recruiting
Sacred Heart Hospital
Pensacola, Florida, United States
Ranjith B. Dissanayake
Recruiting
Um Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States
Chukwuemeka (Emeka) V. Ikpeazu
Recruiting
James A. Haley Veterans Affairs Hospital
Tampa, Florida, United States
Elaine Tan
Recruiting
Moffitt Cancer Center
Tampa, Florida, United States
Mohammed Al-Jumayli
Recruiting

288 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Paclitaxel →Pembrolizumab →Pemetrexed →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 19 Jul 2024
Primary completion: 1 Apr 2039
Completion: 1 Apr 2039
Last update posted: 29 Oct 2026
Registered enrollment: 304
Registry id: NCT06096844

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.