Clinical trialNCT06113016RecruitingPhase 2Interventional

Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors

SponsorJonsson Comprehensive Cancer CenterEnrollment164Anatomic Stage I Breast Cancer American Joint Committee on Cancer (AJCC) v8Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8Early Stage Breast Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial tests how well fisetin and exercise works in preventing frailty in breast cancer survivors. Fisetin is a natural substance found in strawberries and other foods and is available as a nutritional supplement. Nutritional supplements may be useful in eliminating cells that have undergone a process called senescence. Senescence is when a cell ages and permanently stops dividing but does not die. Over time, large numbers of these cells build up in tissues throughout the body and can release harmful substances that cause inflammation and damage nearby healthy cells. Giving fisetin may eliminate senescent cells in patients with breast cancer undergoing physical activity.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Mina S Sedrak
UCLA / Jonsson Comprehensive Cancer Center
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Ucla Health Cancer Care in Alhambra
Alhambra, California, United States
Recruiting
Ucla Health Beverly Hills Primary & Specialty Care
Beverly Hills, California, United States
Recruiting
Ucla Health Burbank Primary & Specialty Care
Burbank, California, United States
Recruiting
Ucla / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States
Mina S. Sedrak
Recruiting
Ucla Health Primary Care in Marina del Rey
Marina del Rey, California, United States
Recruiting
Ucla Health Primary Care in Pasadena
Pasadena, California, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

FisetinPlacebo Administration

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 23 Jul 2024
Primary completion: 31 Oct 2028
Completion: 31 Oct 2031
Last update posted: 30 Jul 2026
Registered enrollment: 164
Registry id: NCT06113016

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.