Clinical trialNCT06143631RecruitingPhase 4Interventional

Prescription of Letrozole for Uterine Myoma

SponsorUniversity of California, San FranciscoEnrollment140FibroidFibroid UterusLeiomyomaLeiomyoma, Uterine

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and quality of life as well as leiomyoma and uterine size.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Alison Huang, MD, MAS
University of California, San Francisco
Principal Investigator
clinicaltrials.gov ↗
Vanessa Jacoby, MD, MAS
University of California, San Francisco
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California, Los Angeles
Los Angeles, California, United States
Jacqueline Fahey, MDRam Parvataneni, MD
Recruiting
University of California, San Francisco
San Francisco, California, United States
Alison Huang, MD, MASVanessa L Jacoby, MD, MAS
Recruiting
Mayo Clinic
Rochester, Minnesota, United States
Sarah Rassier, MD
Recruiting
University of Mississippi Medical Center
Jackson, Mississippi, United States
Elizabeth Lutz, MDKedra Wallace, PhD
Recruiting
Duke University
Durham, North Carolina, United States
Craig Sobolewski, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Letrozole 2.5mg

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 24 Jul 2024
Primary completion: 11 Sept 2028
Completion: 11 Dec 2028
Last update posted: 22 Jul 2026
Registered enrollment: 140
Registry id: NCT06143631

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.