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Clinical trialNCT06158828RecruitingPhase 1/PHASE2Interventional

Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML

SponsorWashington University School of MedicineEnrollment68AML, ChildhoodAcute Myeloid LeukemiaAcute Myeloid Leukemia, PediatricAml
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This trial represents a single institution phase I/II pilot study with the primary objective of establishing the safety and feasibility of generating and infusing ML NK cells after TCRαβ haplo-HCT.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Washington University School of Medicine

    St Louis, Missouri, United States

    Amanda Cashen, M.D.Feng Gao, Ph.D.Melissa Mavers, M.D., Ph.D.Rachel Langley, PharmDRobert Hayashi, M.D.Shalini Shenoy, M.D.Thomas M Pfeiffer, M.D.Todd Fehniger, M.D., Ph.D.
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

BusulfanFludarabine →Granulocyte Colony-Stimulating FactorIL-2Melphalan →Plerixafor →Lymphocyte immune globulin, anti-thymocyte globulin →TCR alpha beta / CD19+ depleted haploidentical hematopoietic progenitor cell graftThiotepaMemory-like natural killer cells
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
15 Nov 2024
Primary completion
15 Sept 2028
Completion
31 May 2030
Last update posted
5 May 2026
Registered enrollment
68
Registry id
NCT06158828
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.