Clinical trialNCT06188585RecruitingInterventional

Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding

SponsorMedtronic - MITGEnrollment278Acute Gastrointestinal Bleeding

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus conventional endoscopic hemostatic therapy in patients presenting with acute overt gastrointestinal bleeding which is found at endoscopy to be due to one of the following sources: a gastric or duodenal ulcer with active bleeding (spurting or oozing) or a non-bleeding visible vessel; an esophageal, gastric or duodenal tumor with active bleeding or a non-bleeding visible vessel; a gastric or duodenal Dieulafoy lesion with active bleeding or a non-bleeding visible vessel; or an actively bleeding Mallory-Weiss tear.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Loren Laine, MD
Yale University
Study ChairKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

14 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Mcgill University
Montreal, Quebec, Canada
Yen-I Chen, M.D.
Recruiting
St. Michael'S Hospital
Toronto, Canada
Jeffrey Mosko, MD, MSc, FRCPC
Recruiting
Vancouver General Hospital
Vancouver, Canada
Roberto Trasolini, MD
Recruiting

Denmark

Copenhagen University Hospital
Hvidovre, Denmark
John G Karstensen
Recruiting
Odense University Hospital
Odense, Denmark
Stig Laursen, MD, PhD
Recruiting

France

St. Antoine
Paris, France
Marine Camus, M.D.
Recruiting

Israel

Emek Medical Center
Afula, Israel
Halim Awadie
Recruiting

United Kingdom

Cleveland Clinic London
London, United Kingdom
Rehan Haidry, M.D.
Recruiting

United States

Yale
New Haven, Connecticut, United States
Kenneth Hung, M.D.
Recruiting
Rush University
Chicago, Illinois, United States
Neal Mehta, M.D.
Recruiting
Brigham and Women'S Hospital
Boston, Massachusetts, United States
Linda Lee, MD
Recruiting
Rutgers University
Piscataway, New Jersey, United States
Arvind Trindade, M.D.
Recruiting
Northwell Health
Manhasset, New York, United States
Juan Bucobo, M.D.
Recruiting
Nyu Langone
New York, New York, United States
Melissa Debordeaux, M.D.
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 21 Jun 2024
Primary completion: 31 Aug 2029
Completion: 30 Sept 2029
Last update posted: 22 Jun 2026
Registered enrollment: 278
Registry id: NCT06188585

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.