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Clinical trialNCT06196879CompletedPhase 2Interventional

A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)

SponsorUpstream Bio Inc.Enrollment479Severe Asthma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to evaluate the efficacy and safety of verekitug (UPB-101) in participants with severe asthma. The study will evaluate the incidence of asthma exacerbations, other pharmacodynamic (PD) parameters such as lung function and asthma control, and the safety and tolerability of verekitug (UPB-101) compared to placebo.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

155 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina
  • Ierim Instituto de Enfermedades Respiratorias E Investigacion Medica

    San Juan Bautista, Buenos Aires, Argentina

  • Centro de Medicina Respiratoria

    Concepción del Uruguay, Entre Ríos Province, Argentina

  • Fundacion Scherbovsky

    Mendoza, Mendoza Province, Argentina

  • Fundacion Estudios Clinicos (feclin)

    Rosario, Santa Fe Province, Argentina

  • Instituto Especialidades de la Salud Rosario

    Rosario, Santa Fe Province, Argentina

  • Investigaciones En Patologias Respiratorias

    San Miguel de Tucumán, Tucumán Province, Argentina

  • Office of Hector H. Altieri Md

    San Miguel de Tucumán, Tucumán Province, Argentina

  • Care: Centro de Alergia Y Enfermedades Respiratorias

    Buenos Aires, Argentina

  • Fundacion Respirar - Centro Medico Dra. de Salvo

    Buenos Aires, Argentina

  • Inaer

    CABA, Argentina

  • Fundacion Cidea

    Caba, Argentina

  • Centro Dr. Lazaro Langer Privado Medicina del Aparato Respiratorio

    Córdoba, Argentina

  • Centro Medico Dharma

    Mendoza, Argentina

  • Insares

    Mendoza, Argentina

Bulgaria
  • Mhat "rahila Angelova" Pernik

    Pernik, Bulgaria

  • Umhat Sveti Georgi

    Plovdiv, Bulgaria

  • Ambulatory for Specialized Outpatient Medical Care - Individual Practice - Dr. Nikolay Evgeniev Ruse Ltd

    Rousse, Bulgaria

  • Dcc Convex

    Sofia, Bulgaria

  • Medconsult Pleven

    Sofia, Bulgaria

  • Medical Center Excelsior

    Sofia, Bulgaria

  • Medical Center Hera Eood

    Sofia, Bulgaria

  • Medical Center Pulmovizhyn

    Sofia, Bulgaria

  • Medical Center New Rehabilitation Center Eood

    Stara Zagora, Bulgaria

  • Mc Zdrave 1

    Vratsa, Bulgaria

Canada
  • Dynamic Drug Advancement

    Ajax, Ontario, Canada

  • Ottawa Allergy Research Corp

    Ottawa, Ontario, Canada

  • Toronto Allergists

    Toronto, Ontario, Canada

  • Winchester Hospital

    Winchester, Ontario, Canada

Chile
  • Fundacion Medica San Cristobal

    Santiago, Santiago Metropolitan, Chile

  • Icegclinic

    Santiago, Santiago Metropolitan, Chile

  • Centro Médico Bioreuma

    Concepción, Chile

  • Cimer

    Providencia, Chile

  • Sociedad Medica Sy G Limitada

    Santiago, Chile

Czechia
  • Fakultni Nemocnice U Sv. Anny V Brne

    Brno, Czech Republic, Czechia

  • Alergologie A Imunologie Hofstetr Alois Mudr. S.R.O.

    Jihlava, Czech Republic, Czechia

  • Plicni Stredisko Teplice S.R.O

    Teplice, Czech Republic, Czechia

  • Pneumologie Varnsdorf S.R.O.

    Varnsdorf, Czech Republic, Czechia

Germany
  • Kppk Studienzentrum

    Koblenz, Rhineland-Palatinate, Germany

  • Pois Sachsen Gmbh

    Leipzig, Saxony, Germany

  • Pneumologisches Studienzentrum

    Berlin, Germany

115 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboVerekitug
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
27 Feb 2024
Primary completion
16 Dec 2025
Completion
19 Mar 2026
Last update posted
1 May 2026
Registered enrollment
479
Registry id
NCT06196879

Cross-registrations

EU-CTR / CTIS (EudraCT)2023-507410-27-00

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.